About: Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV

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About: Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV
Creator	Dziewulska, Daria Koncicki, Andrzej Kowalczyk, Joanna Tykałowski, Bartłomiej Stenzel Id, Tomasz
Source	PMC
abstract	Infections with immunosuppressive pigeon circovirus (PiCV) pose the most severe health problem to the global pigeon breeding. The vaccination with immunogenic PiCV recombinant capsid protein (PiCV rCP) is a potential tool for disease control. Because of the high prevalence of PiCV asymptomatic infections, the subclinically infected pigeons will be vaccinated in practice. The aim of this study was to answer a question if vaccination of asymptomatic, infected with PiCV pigeons induces a similar immune response to PiCV rCP as in uninfected birds. One hundred and twenty 6-week-old carrier pigeons were divided into 4 groups (2 groups of naturally infected and uninfected with PiCV individuals). Birds from groups V and V1 were vaccinated twice with PiCV rCP mixed with an adjuvant, whereas pigeons from groups C and C1 were immunized with an adjuvant only. The expression of genes encoding IFN-γ, CD4, and CD8 T lymphocyte receptors; the number of anti-PiCV rCP IgY-secreting B cells (SBC) and anti-PiCV rCP IgY were evaluated 2, 21, 39 and 46 days post vaccination (dpv). Study results showed that the expression of CD8 and IFN-γ genes was higher in both groups of infected pigeons than in the uninfected birds, irrespective of vaccination. In the uninfected birds, the expression of these genes was insignificantly higher in the vaccinated pigeons. The anti-PiCV rCP IgY-SBC were detected on 2 and 23 dpv and seroconversion was noted on 23 and 39 dpv in V and V1 groups, respectively. In the light of the results obtained, it could be concluded that pigeon circovirus recombinant capsid protein elicits the immune response in both naturally infected and uninfected pigeons, but its rate varies depending on PiCV infectious status. The infection with PiCV masks the potential cellular immune response to the vaccination with PiCV rCP and leads to the suppression of humoral immunity.
has issue date	2019-06-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0219175
bibo:pmid	31251772
has license	cc-by
sha1sum (hex)	e78cecafd32aeadea4fe12d0a7d3f7883d222b58
schema:url	https://doi.org/10.1371/journal.pone.0219175
resource representing a document's title	Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV
has PubMed Central identifier	PMC6599111
has PubMed identifier	31251772
schema:publication	PLoS One
resource representing a document's body	covid:e78cecafd32aeadea4fe12d0a7d3f7883d222b58#body_text
is schema:about of	named entity 'UNINFECTED' named entity 'INFECTED' named entity 'detected' named entity 'pigeons' named entity 'vaccinated' named entity 'adjuvant' named entity 'The infection' named entity 'immune response' named entity 'circovirus' named entity 'pigeons' named entity 'health' named entity 'encoding' named entity 'pigeons' named entity 'capsid' named entity 'immune response' named entity 'PIGEONS' named entity 'RCP' named entity 'MASKS' named entity 'INFECTIOUS' named entity 'OBTAINED' named entity 'AIM' named entity 'MIXED' named entity 'TWICE' named entity 'POTENTIAL' named entity 'POST' named entity 'HEALTH PROBLEM' named entity 'GLOBAL' named entity 'EVALUATED' named entity 'OLD' named entity 'ITS' named entity 'POSE' named entity 'CELLULAR IMMUNE RESPONSE' named entity '282' named entity 'SBC' named entity 'ADJUVANT' named entity 'DETECTED' named entity 'EXPRESSION' named entity 'PIGEON CIRCOVIRUS' named entity 'COULD BE' named entity 'PROTEIN ' named entity 'INFECTION' named entity 'ANSWER' named entity 'ASYMPTOMATIC INFECTIONS' named entity 'VARIES' named entity 'LIGHT' named entity 'ASYMPTOMATIC' named entity 'RESULTS' named entity 'SECRETING' named entity 'CD4' named entity 'INFECTIONS' named entity 'IMMUNOSUPPRESSIVE' named entity 'COMPARISON' named entity 'UNINFECTED' named entity 'IFN' named entity 'DPV' named entity 'DIVIDED' named entity 'WEEK' named entity 'BIRDS' named entity 'NOTED' named entity 'SIMILAR' named entity 'IS A' named entity 'INFECTED' named entity 'NUMBER OF' named entity 'IMMUNIZED' named entity 'GROUPS' named entity 'IMMUNOGENIC' named entity 'VACCINATION' named entity 'IMMUNE RESPONSE' named entity 'RECOMBINANT' named entity 'CAPSID PROTEIN' named entity 'PROTEIN ' named entity 'CARRIER' named entity 'ELICITS' named entity 'INDIVIDUALS' named entity 'QUESTION' named entity 'SEVERE' named entity 'STUDY'

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