About: In vitro rapid clearance of infectious bursal disease virus in peripheral blood mononuclear cells of chicken lines divergent for antibody response might be related to the enhanced expression of proinflammatory cytokines

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About: In vitro rapid clearance of infectious bursal disease virus in peripheral blood mononuclear cells of chicken lines divergent for antibody response might be related to the enhanced expression of proinflammatory cytokines Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro rapid clearance of infectious bursal disease virus in peripheral blood mononuclear cells of chicken lines divergent for antibody response might be related to the enhanced expression of proinflammatory cytokines
Creator	Ahmed, K Jain, Preeti Saxena, M Saxena, V Singh, K Singh, Rani Sundaresan, N Tiwari, A
Source	Elsevier; Medline; PMC
abstract	Abstract Infectious bursal disease (IBD) is an acute and highly contagious viral disease of young chickens caused by infectious bursal disease virus (IBDV). An effective way to control IBDV would be to breed chickens with a reduced susceptibility to IBDV infection. In the present work, we used chickens selected for high and low specific responses to sheep red blood cells (SRBC) (H and L, respectively) to assess the susceptibility of differential immune competent animals to IBDV infection. The peripheral blood mononuclear cells (PBMCs) of high SRBC line (HL) and low SRBC line (LL) were infected with IBDV and viral RNA loads were determined at different time post-IBDV infection. Chicken orthologues of the T helper 1 (Th1) cytokines, interferon-γ (IFN-γ) and interleukin-2 (IL-2); a Th2 cytokine, IL-10; a pro inflammatory cytokine, IL-6; the CCL chemokines, chCCLi2, chCCLi4 and chCCLi7; colony stimulating factor, GM-CSF; and a anti-inflammatory cytokine, transforming growth factor β-2 (TGFβ-2) were quantified. The expression of chCCLi2, chCCLi4 and chCCLi7 was significantly higher in L line as compared to H line. However, in H line the viral RNA loads were significantly lower than in L line. Therefore, the upregulated chemokines might be associated with the susceptibility to IBDV. The expression of IFN-γ, IL-2 and IL-6 was significantly higher in H line as compared to L line. We assume that the higher proinflammatory cytokines expression in H line might be related to the rapid clearance of virus from PBMCs. Significantly higher levels of IL-10 and TGFβ-2 mRNAs in L line might be related to the pathogenesis of IBDV. In conclusion, selection for antibody responses appears to influence the expression profiles of chemokines and cytokines against IBDV. Further, the selection for high SRBC response might improve the immuno-competence of chickens against IBDV.
has issue date	2013-12-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2013.08.018
bibo:pmid	24075224
has license	els-covid
sha1sum (hex)	e7d2b8c9be521d5c6dabee5062fe3acb819f2bb0
schema:url	https://doi.org/10.1016/j.rvsc.2013.08.018
resource representing a document's title	In vitro rapid clearance of infectious bursal disease virus in peripheral blood mononuclear cells of chicken lines divergent for antibody response might be related to the enhanced expression of proinflammatory cytokines
has PubMed Central identifier	PMC7111768
has PubMed identifier	24075224
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:e7d2b8c9be521d5c6dabee5062fe3acb819f2bb0#body_text
is schema:about of	named entity 'IL-10' named entity 'quantified' named entity 'The peripheral' named entity 'expression' named entity 'viral' named entity 'IL-6' named entity 'cytokines' named entity 'compared' named entity '28H' named entity 'POST' named entity 'MRNAS' named entity 'LOW' named entity 'TRANSFORMING GROWTH FACTOR' named entity 'INFLUENCE' named entity 'ACUTE' named entity 'CYTOKINES' named entity 'EFFECTIVE' named entity 'USED' named entity 'IMMUNE' named entity 'VIRUS' named entity 'SRBC' named entity 'WORK' named entity 'IFN' named entity 'CHICKEN' named entity 'DIFFERENTIAL' named entity 'GM-CSF' named entity 'TGFB-2' named entity 'DETERMINED' named entity 'TIME' named entity 'INFECTIOUS BURSAL DISEASE' named entity '10%' named entity 'PRESENT' named entity 'MIGHT BE' named entity 'ANIMALS' named entity 'RELATED' named entity 'SPECIFIC' named entity 'LEVELS' named entity 'COMPETENCE' named entity 'TH2 CYTOKINE' named entity 'PRO' named entity 'ASSOCIATED WITH' named entity 'INFECTION' named entity 'TO CONTROL' named entity 'IBDV' named entity 'HIGH' named entity 'LOWER' named entity 'SHEEP' named entity 'UPREGULATED' named entity 'INTERLEUKIN-2 ' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'IL-2' named entity 'DIFFERENT' named entity 'INFECTIOUS BURSAL DISEASE VIRUS' named entity 'REDUCED' named entity 'ANTI-INFLAMMATORY CYTOKINE' named entity 'COMPETENT' named entity 'ASSESS' named entity 'PBMCS' named entity 'CCL' named entity 'RESPONSES' named entity 'CHEMOKINES' named entity 'RED BLOOD CELLS' named entity 'SELECTION' named entity 'SUSCEPTIBILITY' named entity 'BREED' named entity 'CHICKENS' named entity 'CLEARANCE' named entity 'T HELPER' named entity 'YOUNG' named entity 'IL-6' named entity 'FACTOR B' named entity 'INTERFERON' named entity 'HIGHLY' named entity 'PROINFLAMMATORY CYTOKINES'

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