About: Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns
Creator	Bavari, Sina Kota, Krishna Kenny, Tara Zhong, Yang Che, Jianwei Chiang, Chih-Yuan Lane, Douglas Ribot, Wilson Zhou, Yingyao Langel, Felicia Ojeda, Jenifer Panchal, Rekha
source	Medline; PMC
abstract	Alveolar macrophages (AMs) phagocytose Bacillus anthracis following inhalation and induce the production of pro-inflammatory cytokines and chemokines to mediate the activation of innate immunity. Ames, the virulent strain of B. anthracis, contains two plasmids that encode the antiphagocytic poly-γ-d-glutamic acid capsule and the lethal toxin. The attenuated Sterne strain of B. anthracis, which lacks the plasmid encoding capsule, is widely adapted as a vaccine strain. Although differences in the outcome of infection with the two strains may have originated from the presence or absence of an anti-phagocytic capsule, the disease pathogenesis following infection will be manifested via the host responses, which is not well understood. To gain understanding of the host responses at cellular level, a microarray analysis was performed using primary rhesus macaque AMs infected with either Ames or Sterne spores. Notably, 528 human orthologs were identified to be differentially expressed in AMs infected with either strain of the B. anthracis. Meta-analyses revealed genes differentially expressed in response to B. anthracis infection were also induced upon infections with multiple pathogens such as Francisella Novicida or Staphylococcus aureus. This suggests the existence of a common molecular signature in response to pathogen infections. Importantly, the microarray and protein expression data for certain cytokines, chemokines and host factors provide further insights on how cellular processes such as innate immune sensing pathways, anti-apoptosis versus apoptosis may be differentially modulated in response to the virulent or vaccine strain of B. anthracis. The reported differences may account for the marked difference in pathogenicity between these two strains.
has issue date	2014-02-07(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0087201
bibo:pmid	24516547
has license	cc0
sha1sum (hex)	e8679d8c149ea6d25afb92e8a4f4b622dadcd872
schema:url	https://doi.org/10.1371/journal.pone.0087201
resource representing a document's title	Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns
has PubMed Central identifier	PMC3917846
has PubMed identifier	24516547
schema:publication	PLoS One
resource representing a document's body	covid:e8679d8c149ea6d25afb92e8a4f4b622dadcd872#body_text
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