About: Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients

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About: Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients
Creator	Baldanti, Fausto Campanini, Giulia Rovida, Francesca Gerna, Giuseppe Oggionni, Tiberio Lilleri, Daniele Revello, M Pellegrini, Carlo Vitulo, Patrizio
Source	Medline; PMC
abstract	Viral respiratory tract infections in lung transplant recipients may be severe. During three consecutive winter‐spring seasons, 49 symptomatic lung transplant recipients with suspected respiratory viral infection, and 26 asymptomatic patients were investigated for presence of respiratory viruses either in 56 nasopharyngeal aspirate or 72 bronchoalveolar lavage samples taken at different times after transplantation. On the whole, 1 asymptomatic (3.4%) and 28 symptomatic (57.1%) patients were positive for human metapneumovirus (hMPV, 4 patients), influenza virus A (3 patients), and B (2 patients), respiratory syncytial virus (2 patients), human coronavirus (2 patients), human parainfluenza virus (2 patients), rhinovirus (5 patients), while 4 patients were coinfected by 2 respiratory viruses, and 5 were infected sequentially by 2 or more respiratory viruses. In bronchoalveolar lavage samples, hMPV predominated by far over the other viruses, being responsible for 60% of positive specimens, whereas other viruses were present in nasopharyngeal aspirates at a comparable rate. RT‐PCR (detecting 43 positive samples/128 examined) was largely superior to monoclonal antibodies (detecting 17 positive samples only). In addition, HCMV was detected in association with a respiratory virus in 4/18 HCMV‐positive patients, and was found at a high concentration (>10(5) DNA copies/ml) in 3/16 (18.7%) patients with HCMV‐positive bronchoalveolar lavage samples and pneumonia. Coinfections and sequential infections by HCMV and respiratory viruses were significantly more frequent in patients with acute rejection and steroid treatment. In conclusion: (i) about 50% of respiratory tract infections of lung transplant recipients were associated with one or more respiratory viruses; (ii) hMPV largely predominates in bronchoalveolar lavage of symptomatic lung transplant recipients, thus suggesting a causative role in lower respiratory tract infections; (iii) RT‐PCR appears to be the method of choice for detection of respiratory viruses in lung transplant recipients, (iv) a high HCMV load in bronchoalveolar lavage is a risk factor for viral pneumonia, suggesting some measure of intervention for the control of viral infection. J. Med. Virol. 78:408–416, 2006. © 2006 Wiley‐Liss, Inc.
has issue date	2006-01-17(xsd:dateTime)
bibo:doi	10.1002/jmv.20555
bibo:pmid	16419110
has license	no-cc
sha1sum (hex)	e892cf647d0864ce8ce65a5c7e2520df48694cd9
schema:url	https://doi.org/10.1002/jmv.20555
resource representing a document's title	Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients
has PubMed Central identifier	PMC7166633
has PubMed identifier	16419110
schema:publication	J Med Virol
resource representing a document's body	covid:e892cf647d0864ce8ce65a5c7e2520df48694cd9#body_text
is schema:about of	named entity 'Other' named entity 'Lung Transplant' named entity 'Human Metapneumovirus' named entity 'coinfections' named entity 'antiviral therapy' named entity 'plasmid' named entity 'lungs' named entity 'bronchoalveolar lavage' named entity 'PCR-based' named entity 'influenza viruses' named entity 'symptom' named entity 'quantitation' named entity 'hMPV' named entity 'chest X-rays' named entity 'human coronavirus' named entity 'human cytomegalovirus' named entity 'viral pneumonia' named entity 'fungal infection' named entity 'HCMV' named entity 'acute infection' named entity 'bacterial infections' named entity 'PCR' named entity 'ribavirin' named entity 'Applied Biosystems' named entity 'primer' named entity 'organ' named entity 'sputum' named entity 'viruses' named entity 'bronchoalveolar lavage' named entity 'acute rejection' named entity 'ganciclovir' named entity 'infection' named entity 'nasopharyngeal' named entity 'fluorochrome' named entity 'ganciclovir' named entity 'antiviral treatment' named entity 'lung transplant' named entity 'nasopharyngeal' named entity 'lung transplant' named entity 'viruses' named entity 'HCMV' named entity 'human coronaviruses' named entity 'plasmid vector' named entity 'Carlsbad, CA' named entity 'nasopharyngeal' named entity 'hMPV' named entity 'cofactors' named entity 'lung transplant' named entity 'HCMV' named entity 'bronchoalveolar lavage' named entity 'monoclonal antibodies' named entity 'lung transplant' named entity 'dendritic cells' named entity 'lung transplant' named entity 'Foster City' named entity 'HCMV' named entity 'Warrington' named entity 'fever' named entity 'respiratory infections' named entity 'coinfections' named entity 'bronchoalveolar lavage' named entity 'lung transplant' named entity 'dyspnoea' named entity 'HCMV' named entity 'viruses' named entity '229E' named entity 'virus' named entity 'Taq polymerase' named entity 'relative risk' named entity 'nasopharyngeal' named entity 'virus' named entity 'HCMV' named entity 'antiviral treatment'

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