About: Autopsia clínica en Síndrome Respiratorio Agudo Severo por SARS-CoV-2. Primer fallecido conocido en España

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About: Autopsia clínica en Síndrome Respiratorio Agudo Severo por SARS-CoV-2. Primer fallecido conocido en España Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autopsia clínica en Síndrome Respiratorio Agudo Severo por SARS-CoV-2. Primer fallecido conocido en España
Creator	Carlos, Juan Alemany, Pilar Aranda, Mayordomo Carmen, Monraval Conde, Pedro Empar, Santos Ferrando, José Medina, Medina Puglia, Marco Sánchez, Ana Teruel, Andrés
Source	Elsevier; Medline; PMC
abstract	Resumen El nuevo coronavirus SARS-CoV-2, identificado inicialmente en China en diciembre de 2019 puede cursar con un Síndrome Respiratorio Agudo Severo (SARS) con daño alveolar masivo y fracaso respiratorio progresivo. Presentamos los hallazgos más relevantes encontrados en la autopsia clínica efectuada en nuestro hospital (Hospital Arnau de Vilanova-Lliria de Valencia) a fecha de 14 de febrero de 2020, al primer paciente fallecido conocido en España por neumonía COVID-19. A nivel pulmonar, la autopsia revela cambios típicos de daño alveolar difuso (DAD) en fase exudativa y fase proliferativa. Se observan células multinucleadas gigantes, células tipo smudge intraalveolares y trombosis vasculares. El diagnóstico microbiológico confirmativo mediante PCR se realizó 15 días después de la autopsia sobre la muestra faríngea del enfermo tomada durante su ingreso. Abstract The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14th of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed changes typical of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient’s admission. The positive result was reported fifteen days subsequent to autopsy.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1016/j.patol.2020.04.002
bibo:pmid	32650970
has license	els-covid
sha1sum (hex)	e90d71ee6e5b47c0fce77aa3b4b2d5147cafd42d
schema:url	https://doi.org/10.1016/j.patol.2020.04.002
resource representing a document's title	Autopsia clínica en Síndrome Respiratorio Agudo Severo por SARS-CoV-2. Primer fallecido conocido en España
has PubMed Central identifier	PMC7211676
has PubMed identifier	32650970
schema:publication	Rev Esp Patol
resource representing a document's body	covid:e90d71ee6e5b47c0fce77aa3b4b2d5147cafd42d#body_text
is schema:about of	named entity 'pneumology' named entity 'Journal' named entity 'SARS-CoV-2' named entity 'desquamation' named entity 'macrophages' named entity 'autopsy' named entity 'H&E' named entity 'autopsia' named entity 'Pleural adhesions' named entity 'Wuhan' named entity 'emergency department' named entity 'pneumonia' named entity 'parenchyma' named entity 'Arnau de Vilanova' named entity 'nuclei' named entity 'PCR' named entity 'AUTOPSY' named entity 'AE1/AE3' named entity 'COVID' named entity 'cytopathic' named entity 'pneumonia' named entity 'immunohistochemical' named entity 'Arnau de Vilanova' named entity 'eosinophilic cells' named entity 'respiratory disease' named entity 'autopsy' named entity 'renal failure' named entity 'asymptomatic' named entity 'evolution' named entity 'lungs' named entity 'pneumonia' named entity 'herpes simplex virus' named entity 'infection' named entity 'haemorrhage' named entity 'viruses' named entity 'COVID' named entity 'Epidemiological' named entity 'morphological' named entity 'autopsia' named entity 'hypertension' named entity 'hyaline' named entity 'COVID' named entity 'hypoxia' named entity 'alveolar' named entity 'postmortem' named entity 'immunohistochemistry' named entity 'pneumonia' named entity 'collagen' named entity 'pulmonary lobe' named entity 'China' named entity 'coinfection' named entity 'hepatitis' named entity 'haemorrhage' named entity 'biopsies' named entity 'formalin' named entity 'urothelial carcinoma' named entity 'microbiological analysis' named entity 'influenza' named entity 'China' named entity 'Spain' named entity 'parenchyma' named entity 'adenovirus' named entity 'Antibiotic treatment' named entity 'diabetes mellitus' named entity 'ICU' named entity 'upper respiratory tract infection' named entity 'Wuhan' named entity 'DAD' named entity 'Infectious Diseases' named entity 'H1N1' named entity 'pulmonary thromboembolism'

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