About: Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells

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About: Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells
Creator	Fernández Bussy, Rodrigo Manarin, Romina Piaggio, Eliane Pilon, Caroline Pérol, Louis Bottasso, Oscar Cohen, José González, Florencia Martin, Gaëlle Pérez, Ana Spinelli, Silvana Villar, Silvina
Source	Elsevier; Medline; PMC
abstract	Abstract We previously showed that Trypanosoma cruzi infection in C57BL/6 mice results in a lethal infection linked to unbalanced pro- and anti-inflammatory mediators production. Here, we examined the dynamics of CD4+Foxp3+ regulatory T (Treg) cells within this inflammatory and highly Th1-polarized environment. Treg cells showed a reduced proliferation rate and their frequency is progressively reduced along infection compared to effector T (Teff) cells. Also, a higher fraction of Treg cells showed a naïve phenotype, meanwhile Teff cells were mostly of the effector memory type. T. cruzi infection was associated with the production of pro- and anti-inflammatory cytokines, notably IL-27p28, and with the induction of T-bet and IFN-γ expression in Treg cells. Furthermore, endogenous glucocorticoids released in response to T. cruzi-driven immune activation were crucial to sustain the Treg/Teff cell balance. Notably, IL-2 plus dexamethasone combined treatment before infection was associated with increased Treg cell proliferation and expression of GATA-3, IL-4 and IL-10, and increased mice survival time. Overall, our results indicate that therapies aimed at specifically boosting Treg cells, which during T. cruzi infection are overwhelmed by the effector immune response, represent new opportunities for the treatment of Chagas disease, which is actually only based on parasite-targeted chemotherapy.
has issue date	2015-03-31(xsd:dateTime)
bibo:doi	10.1016/j.bbi.2014.11.016
bibo:pmid	25483139
has license	els-covid
sha1sum (hex)	e92122ce25ebe0f1793d8ad3a72c51a9de790197
schema:url	https://doi.org/10.1016/j.bbi.2014.11.016
resource representing a document's title	Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells
has PubMed Central identifier	PMC7126853
has PubMed identifier	25483139
schema:publication	Brain, Behavior, and Immunity
resource representing a document's body	covid:e92122ce25ebe0f1793d8ad3a72c51a9de790197#body_text
is schema:about of	named entity 'ACQUISITION' named entity 'based' named entity 'glucocorticoids' named entity 'fraction' named entity 'infection' named entity 'production' named entity 'linked' named entity 'T. cruzi' named entity 'infection' named entity 'T CELLS' named entity 'CELL' named entity '10%' named entity 'PRODUCTION' named entity 'DRIVEN' named entity 'OUR' named entity 'IL-27P28' named entity 'NEW' named entity 'EFFECTOR' named entity 'TREG' named entity 'EXAMINED' named entity 'ENDOGENOUS' named entity 'RESULTS' named entity 'INFLAMMATORY' named entity 'CYTOKINES' named entity 'TH-1' named entity 'UNBALANCED' named entity 'INFECTION' named entity 'ASSOCIATED WITH' named entity 'ENVIRONMENT' named entity 'T-BET' named entity 'PARASITE' named entity 'BASED' named entity 'PRO-' named entity 'UNCONTROLLED' named entity 'PHENOTYPE' named entity 'FOXP3' named entity 'TH1' named entity 'C57BL' named entity 'LETHAL INFECTION' named entity 'TYPE' named entity 'CHEMOTHERAPY' named entity 'OVERALL' named entity 'INCREASED' named entity 'FREQUENCY' named entity 'LIKE' named entity 'TARGETED' named entity 'IMMUNE RESPONSE' named entity 'FOXP3' named entity 'RESPONSE TO' named entity 'CELLS' named entity 'DYNAMICS' named entity 'TREG CELL' named entity 'SUSTAIN' named entity 'TREATMENT' named entity 'SURVIVAL TIME' named entity 'RELEASED' named entity 'INDUCTION' named entity 'PROLIFERATION' named entity 'HIGHLY' named entity 'PREVIOUSLY' named entity 'ASSOCIATED WITH' named entity 'THEIR' named entity 'REPRESENT' named entity 'EXPRESSION' named entity 'BALANCE' named entity 'REGULATORY' named entity 'GATA-3' named entity 'CHAGAS DISEASE' named entity 'COMBINED TREATMENT' named entity 'FRACTION OF'

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