About: 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

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About: 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
Creator	Wu, Yang-Chang Chang, Cheng-Hsien Chang, Fang-Rong Cheng, Pei-Wen Chiang, Lien-Chai Hsieh, Pei-Wen Lin, Kuei-Hsiang Zeng, Fu-Long
Source	Elsevier; Medline; PMC
abstract	Abstract A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED50 values of 1 and 6 are 1.00 and 0.50μg/mL, respectively.
has issue date	2004-09-20(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2004.06.083
bibo:pmid	15324901
has license	els-covid
sha1sum (hex)	e93ad2ad85038fefc8cec11e8a2233aa6dd44fb2
schema:url	https://doi.org/10.1016/j.bmcl.2004.06.083
resource representing a document's title	2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
has PubMed Central identifier	PMC7126427
has PubMed identifier	15324901
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:e93ad2ad85038fefc8cec11e8a2233aa6dd44fb2#body_text
is schema:about of	named entity 'INHIBITORY EFFECT' named entity 'BENZOXAZINONES' named entity 'THESE' named entity 'SERIES' covid:arg/e93ad2ad85038fefc8cec11e8a2233aa6dd44fb2 named entity 'EXPRESSION' named entity 'ACTIVITIES' named entity 'VALUES' named entity 'SIGNIFICANT' named entity 'ICAM-1' named entity 'VALUE' named entity 'SYNTHESIZED' named entity 'HUMAN CORONAVIRUS' named entity 'INHIBITION' named entity 'ED 50' named entity 'vascular cell adhesion molecule 1' named entity 'C1r' named entity 'expression' named entity 'inhibition' named entity 'MRC-5' named entity 'phytoalexin' named entity 'SARS-CoV' named entity 'Phenyl' named entity 'anti-viral' named entity 'naphthalene' named entity 'DMEM' named entity 'H NMR' named entity 'bioactivities' named entity 'protease' named entity 'ICAM-1' named entity 'pulmonary edema' named entity 'fulminant' named entity 'infection' named entity 'serine' named entity 'serine protease' named entity 'assay' named entity 'ICAM-1' named entity 'cathepsin' named entity 'virus' named entity '37°C' named entity 'Dianthus' named entity 'SARS' named entity 'protease inhibitors' named entity 'adhesion molecules' named entity 'E-selectin' named entity 'anti-inflammatory' named entity 'Actinomycin D' named entity 'Phytophthora parasitica' named entity 'antifungal activity' named entity 'incubation' named entity '229E' named entity '37°C' named entity 'protein' named entity 'proteinase' named entity 'research and development' named entity 'carboxylic acid' named entity 'SARS-associated coronavirus' named entity 'positive control' named entity 'P. parasitica' named entity 'chymase' named entity 'infection' named entity 'Actinomycin' named entity 'complement' named entity 'anti-inflammatory agents' named entity 'microliters' named entity 'Human coronaviruses' named entity 'HSV-1' named entity 'treating SARS' named entity 'atypical pneumonia' named entity 'structure-activity relationship' named entity 'computational modeling' named entity 'traditional Chinese medicine' named entity 'Caryophyllaceae' named entity 'virus entry'

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