About: p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration

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About: p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration
Creator	Zhang, Ting Xian, Wa Liew, Audrey-Ann Wang, Xia Lim, Siew Wu, An Zuo, Wei Crum, Christopher Guan, Shou Lessard, Mark Mckeon, Frank Vincent, Matthew Yamamoto, Yusuke Zheng', Daniel
source	PMC
abstract	Lung diseases such as chronic obstructive pulmonary disease(1) and pulmonary fibrosis(2) involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and the possibility of regenerative medicine has lacked empirical support. However, it is clinically known that patients who survive sudden, massive loss of lung tissue from necrotizing pneumonia(3,4) or acute respiratory distress syndrome(5,6) often recover full pulmonary function within six months. Correspondingly, we recently demonstrated lung regeneration in mice following H1N1 influenza virus infection, and linked distal airway stem cells expressing Trp63 (p63) and keratin 5, called DASC(p63/Krt5), to this process(7). Here we show that pre-existing, intrinsically committed DASC(p63/Krt5) undergo a proliferative expansion in response to influenza-induced lung damage, and assemble into nascent alveoli at sites of interstitial lung inflammation. We also show that the selective ablation of DASC(p63/Krt5) in vivo prevents this regeneration, leading to pre-fibrotic lesions and deficient oxygen exchange. Finally, we demonstrate that single DASC(p63/Krt5)-derived pedigrees differentiate to type I and type II pneumocytes as well as bronchiolar secretory cells following transplantation to infected lung and also minimize the structural consequences of endogenous stem cell loss on this process. The ability to propagate these cells in culture while maintaining their intrinsic lineage commitment suggests their potential in stem cell-based therapies for acute and chronic lung diseases. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature13903) contains supplementary material, which is available to authorized users.
has issue date	2014-11-12(xsd:dateTime)
bibo:doi	10.1038/nature13903
bibo:pmid	25383540
has license	no-cc
sha1sum (hex)	e975131b2e56043ee0916fbe1bd4a920ef145b2f
schema:url	https://doi.org/10.1038/nature13903
resource representing a document's title	p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration
has PubMed Central identifier	PMC7095488
has PubMed identifier	25383540
schema:publication	Nature
resource representing a document's body	covid:e975131b2e56043ee0916fbe1bd4a920ef145b2f#body_text
is schema:about of	named entity 'therapies' named entity 'Lung diseases' named entity 'massive' named entity 'mice' named entity 'lung inflammation' named entity 'exchange' named entity 'demonstrated' named entity 'Krt5' named entity 'TYPE II' named entity 'DEFICIENT' named entity 'THERAPIES' named entity 'CELLS' named entity 'ENDOGENOUS' covid:arg/e975131b2e56043ee0916fbe1bd4a920ef145b2f named entity 'lung' named entity 'propagate' named entity 'stem' named entity 'intrinsically' named entity 'necrotizing pneumonia' named entity 'p63' named entity 'p63' named entity 'response' named entity 'exchange' named entity 'vivo' named entity 'lung diseases' named entity 'stem cell' named entity 'emerged' named entity 'endogenous' named entity 'patients' named entity 'called' named entity 'pulmonary fibrosis' named entity 'fibrotic' named entity 'oxygen exchange' named entity 'acute respiratory distress syndrome' named entity 'airway' named entity 'stem cell' named entity 'oxygen exchange' named entity 'H1N1' named entity 'regeneration' named entity 'maintaining' named entity 'gene expression' named entity 'genome expression' named entity 'Krt5' named entity 'long-term' named entity 'Germany' named entity 'Krt5' named entity 'intraperitoneal injection' named entity 'hybridized' named entity 'infection' named entity 'feeder cells' named entity 'gene' named entity 'Germany' named entity 'bronchioles' named entity 'self-renewal' named entity 'Krt6a' named entity 'H1N1' named entity 'type II' named entity 'pneumocytes' named entity 'infection' named entity 'ethanol' named entity 'antibodies' named entity 'Arcturus' named entity 'type II pneumocytes' named entity 'body weight' named entity 'vasculature' named entity 'formaldehyde' named entity 'Krt5' named entity 'anaesthetized'

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