About: Central Nervous System Manifestations in COVID-19 Patients: A Systematic Review and Meta-analysis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Central Nervous System Manifestations in COVID-19 Patients: A Systematic Review and Meta-analysis
Creator	Mohammad, ; Seyed, ; Alikhani, Katayoun Amirhossein, ; Asarzadegan, Farhad Dalvand, Sahar Ebadi, Hamid Fathi, Davood Heidari, Eghbal Jafari, Azari Mirmoeeni, Seyyedmohammadsadeq Nazari, Shahrzad Puormand, Mahmoud Sadeghian, Saeid Sadeghian, Siavash
source	MedRxiv
abstract	Background: At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID-19 initially reported in China, and later known as COVID-19, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations in COVID-19. In this study, we aimed to evaluate the CNS presentations in COVID-19 patients in an attempt to identify the common CNS features and provide a better overview to tackle this new pandemic. Methods: In this systematic review and meta-analysis, we searched PubMed, Web of Science, Ovid, Embase, Scopus, and Google Scholar. Included studies were publications that reported the CNS features between January 1st, 2020, to April 20th, 2020. The data of selected studies were screened and extracted independently by four reviewers. Extracted data analyzed by using STATA statistical software. The study protocol registered with PROSPERO (CRD42020184456). Results: Of 2353 retrieved studies, we selected 64 studies with 11282 patients after screening. Most of the studies were conducted in China (58 studies). The most common CNS symptom of COVID-19 were Headache (8.69%, 95%CI: 6.76%-10.82%), Dizziness (5.94%, 95%CI: 3.66%-8.22%), and Impaired consciousness (1.9%, 95%CI: 1%-2.79%). Conclusions: The growing number of studies have reported COVID-19, CNS presentations as remarkable manifestations that happen. Hence, understanding the CNS characteristics of COVID-19 can help us for better diagnosis and ultimately prevention of worse outcomes.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.20158691
has license	medrxiv
sha1sum (hex)	e991f38248de230f2700cddff82fa0fa08136445
schema:url	https://doi.org/10.1101/2020.07.21.20158691
resource representing a document's title	Central Nervous System Manifestations in COVID-19 Patients: A Systematic Review and Meta-analysis
resource representing a document's body	covid:e991f38248de230f2700cddff82fa0fa08136445#body_text
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