About: A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice

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About: A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice
Creator	Wang, Ping Brenner, Max Yang, Weng-Lang Zhang, Fangming
Source	PMC
abstract	Cold-inducible RNA-binding protein (CIRP) is a novel sepsis inflammatory mediator and C23 is a putative CIRP competitive inhibitor. Therefore, we hypothesized that C23 can ameliorate sepsis-associated injury to the lungs and kidneys. First, we confirmed that C23 dose-dependently inhibited TNF-α release, IκBα degradation, and NF-κB nuclear translocation in macrophages stimulated with CIRP. Next, we observed that male C57BL/6 mice treated with C23 (8 mg/kg BW) at 2 h after cecal ligation and puncture (CLP) had lower serum levels of LDH, ALT, IL-6, TNF-α, and IL-1β (reduced by ≥39%) at 20 h after CLP compared with mice treated with vehicle. C23-treated mice also had improved lung histology, less TUNEL-positive cells, lower serum levels of creatinine (34%) and BUN (26%), and lower kidney expression of NGAL (50%) and KIM-1 (86%). C23-treated mice also had reduced lung and kidney levels of IL-6, TNF-α, and IL-1β. E-selectin and ICAM-1 mRNA was significantly lower in C23-treated mice. The 10-day survival after CLP of vehicle-treated mice was 55%, while that of C23-treated mice was 85%. In summary, C23 decreased systemic, lung, and kidney injury and inflammation, and improved the survival rate after CLP, suggesting that it may be developed as a new treatment for sepsis.
has issue date	2018-02-12(xsd:dateTime)
bibo:doi	10.1038/s41598-017-13139-z
bibo:pmid	29434211
has license	cc-by
sha1sum (hex)	ea0546ceed5845d680cb318bad2107b22e238351
schema:url	https://doi.org/10.1038/s41598-017-13139-z
resource representing a document's title	A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice
has PubMed Central identifier	PMC5809586
has PubMed identifier	29434211
schema:publication	Sci Rep
resource representing a document's body	covid:ea0546ceed5845d680cb318bad2107b22e238351#body_text
is schema:about of	named entity 'Next' named entity 'systemic' named entity 'levels' named entity 'injury' named entity 'TREATED WITH' named entity 'KIDNEY' named entity 'COMPETITIVE INHIBITOR' named entity 'NF-' named entity 'DEGRADATION' named entity 'SUMMARY' named entity 'CIRP' named entity 'SERUM' named entity 'ICAM-1' named entity 'IMPROVED' named entity 'STIMULATED' named entity 'MAY BE' named entity 'C23' named entity 'EXPRESSION' named entity 'IL-1' named entity 'mice' named entity 'IL-1β' named entity 'mice' named entity 'mice' named entity 'treated' named entity 'degradation' named entity 'kidneys' named entity 'ligation' named entity 'lungs' named entity 'IL-1β' named entity 'IL-6' named entity 'IL-1β' named entity 'ICAM-1' named entity 'creatinine' named entity 'NF-κB' named entity 'cecal' named entity 'kidney injury' named entity 'survival rate' named entity 'IL-6' named entity 'organ' named entity 'RNA-binding protein' named entity 'inflammation' named entity 'ALT' named entity 'mRNA' named entity 'cells' named entity 'necroptotic' named entity 'lung injury' named entity 'half-life' named entity 'oxidative stress' named entity 'extracellular' named entity 'Collection of blood' named entity 'cytosolic' named entity 'Histological examination' named entity 'sepsis' named entity 'sepsis' named entity 'protein' named entity 'Billerica' named entity 'edema' named entity 'sham-operated' named entity 'Serum levels' named entity 'lungs' named entity 'receptor complex' named entity 'isoflurane' named entity 'interleukin 1β' named entity 'ventral' named entity 'serum levels' named entity 'Feinstein Institute for Medical Research' named entity 'therapeutic strategies' named entity 'laparotomy' named entity 'standard error' named entity 'ALI' named entity 'leukocyte' named entity 'macrophages' named entity 'mice' named entity 'peritoneal' named entity 'ICAM-1' named entity 'mice' named entity 'systemic inflammation' named entity 'mice'

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