About: COVID-19 in pregnancy was associated with maternal morbidity and preterm birth

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About: COVID-19 in pregnancy was associated with maternal morbidity and preterm birth Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 in pregnancy was associated with maternal morbidity and preterm birth
Creator	Fafi-Kremer, Samira De Marcillac, Fanny Deruelle, Philippe Hansmann, Yves Jouffrieau, Charlotte Kuhn, Pierre Ruch, Yvon Sentilhes, Loïc Thuet, Vincent
source	Elsevier; Medline; PMC
abstract	Abstract Background Despite the mainly reassuring outcomes for pregnant women with COVID-19 infection reported by previous case series with small sample sizes, some recent reports of severe maternal morbidity requiring intubation and of maternal deaths show the need for additional data about the impact of COVID-19 on pregnancy outcomes. This study aimed to report the maternal characteristics and clinical outcomes of pregnant women with COVID-19 disease. Study design This retrospective single-center study includes all consecutive pregnant women with confirmed (laboratory-confirmed) or suspected (according to version 7.0 of the Chinese management guideline) COVID-19 infection, regardless of gestational age at diagnosis, admitted to the Strasbourg University Hospital (France) from March 1 to April 3, 2020. Maternal characteristics, laboratory and imaging findings, and maternal and neonatal outcomes were extracted from medical records. Results The study includes 54 pregnant women with confirmed (n=38) and suspected (n=16) COVID-19 infection. Of these, 32 had an ongoing pregnancy, one a miscarriage, and 21 live births: 12 vaginal and 9 cesarean deliveries. Among the women who gave birth, preterm deliveries were medically indicated for their COVID-19-related condition for 23.8% (5/21): 14.3% (3/21) before 32 weeks' gestation and 9.5% (2/21) before 28 weeks. Oxygen support was required for 24.1% (13/54), including high flow oxygen (n=2), noninvasive (n=1) and invasive (n=3) mechanical ventilation, and extracorporeal membrane oxygenation (n=1). Of these, three, aged 35 years or older with positive COVID-19 RT-PCR, had respiratory failure requiring indicated delivery before 29 weeks' gestation. All three women were overweight or obese, and two had an additional comorbidity. Conclusion COVID-19 in pregnancy was associated with maternal morbidity and preterm birth. Its association with other well-known risk factors for severe maternal morbidity in noninfected pregnant women, including maternal age above 35 years, overweight, and obesity, suggests further studies are required to determine whether these risk factors are also associated with poorer maternal outcome in these women.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1016/j.ajog.2020.06.022
bibo:pmid	32553908
has license	els-covid
sha1sum (hex)	ea1368768d2170d7ef7ba01a8cf053e1104a4539
schema:url	https://doi.org/10.1016/j.ajog.2020.06.022
resource representing a document's title	COVID-19 in pregnancy was associated with maternal morbidity and preterm birth
has PubMed Central identifier	PMC7294260
has PubMed identifier	32553908
schema:publication	Am J Obstet Gynecol
resource representing a document's body	covid:ea1368768d2170d7ef7ba01a8cf053e1104a4539#body_text
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