About: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).

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About: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).
Creator	Mitchell, Elizabeth Sharma, Chetan Blaufox, Andrew Friedman, Richard Ganigara, Madhusudan Samuel, Sharmeen Schleien, Charles Zucker, Barbara Children', Cohen
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially pro-arrhythmic Hydroxychloroquine (HCQ) and Azithromycin (AZN). OBJECTIVES: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. METHODS: A single center retrospective chart review was undertaken and included all patients with 1) symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. RESULTS: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (non-sustained (ns) ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic anti-arrhythmic therapy. Patients with significant arrhythmias were likely to have non-cardiac co-morbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, p=1). The use of HCQ with or without AZN was associated with statistically significant QTc prolongation (411+19 msec vs 426+15 msec, p<0.0001). QTc was not statistically different in patients with and without arrhythmias (425+15 msec vs 425+15 msec, p=1). CONCLUSIONS: In pediatric patients with PCR positive active COVID-19 infection, significant arrhythmias are infrequent, but more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation, but was not associated with arrhythmias in pediatric patients.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1016/j.hrthm.2020.06.033
bibo:pmid	32621881
has license	no-cc
sha1sum (hex)	ea47aff095d821a8faee07eada30cfe48bf89778
schema:url	https://doi.org/10.1016/j.hrthm.2020.06.033
resource representing a document's title	INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).
has PubMed Central identifier	PMC7328618
has PubMed identifier	32621881
schema:publication	Heart Rhythm
resource representing a document's body	covid:ea47aff095d821a8faee07eada30cfe48bf89778#body_text
is schema:about of	named entity 'PCR' named entity 'Cardiology' named entity 'electrophysiologic' named entity 'left ventricular ejection fraction' named entity 'arrhythmias' named entity 'PCR' named entity 'ARRHYTHMIAS' named entity 'ELECTROPHYSIOLOGIC' named entity 'QTc' named entity 'Pediatric Cardiology' named entity 'INFECTION' named entity 'INFECTION' named entity 'AZN' named entity 'arrhythmias' named entity 'electrolyte' named entity 'QTc' named entity 'coronavirus disease 2019' named entity 'HCQ' named entity 'arrhythmias' named entity 'COVID-19' named entity 'statistically significantly' named entity 'ECG' named entity 'arrhythmias' named entity '4/6' named entity 'ECG' named entity 'HCQ' named entity 'nasopharyngeal' named entity 'arrhythmias' named entity 'HCQ' named entity 'arrhythmias' named entity 'COVID' named entity 'COVID' named entity 'COVID' named entity 'COVID' named entity 'virus' named entity 'Tocilizumab' named entity 'COVID-19' named entity 'arrhythmias' named entity 'cough' named entity 'SARS-CoV-2 virus' named entity 'virus' named entity 'conduction abnormalities' named entity 'electrophysiologist' named entity 'data set' named entity 'electrophysiologic' named entity 'VSD' named entity 'coronary artery disease' named entity 'hematological' named entity 'HCN' named entity '4/6' named entity 'Hydroxychloroquine' named entity 'ST segment' named entity 'pathophysiologic' named entity 'QTc' named entity 'QTc' named entity 'AZN' named entity 'Echocardiograms' named entity 'Infectious Disease' named entity 'Tocilizumab' named entity 'hemodynamic' named entity 'arrhythmia' named entity 'arrhythmias' named entity 'hypoxia' named entity 'pediatric patients' named entity 'oncologic' named entity 'telemetry' named entity 'selection bias' named entity 'troponin' named entity 'torsades de pointes' named entity 'msec' named entity 'infection' named entity 'Arrhythmias' named entity 'COVID-19'

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