About: Immunity after natural exposure to enteric canine coronavirus does not provide complete protection against infection with the new pantropic CB/05 strain

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immunity after natural exposure to enteric canine coronavirus does not provide complete protection against infection with the new pantropic CB/05 strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunity after natural exposure to enteric canine coronavirus does not provide complete protection against infection with the new pantropic CB/05 strain
Creator	Buonavoglia, Canio Campolo, Marco Decaro, Nicola Desario, Costantina Elia, Gabriella Mari, Viviana Martella, Vito Lorusso, Eleonora Gibbons, Rachel Kanellos, Theofanis Lucente, Maria
Source	Elsevier; Medline; PMC
abstract	Abstract Recently, an outbreak of fatal infection caused by a pantropic variant (strain CB/05) of canine coronavirus (CCoV) has been reported. In this study, evidence is provided that immunity induced by natural exposure to enteric CCoV is not fully protective against strain CB/05. Twenty-two, 10-week-old beagles with a recent natural infection by enteric CCoV were randomly distributed in two experimental groups of eight (groups A and B) and one control group of six (group C) dogs. Dogs in groups A and B were inoculated oronasally with different doses (4×105 or 4×103 TCID50) of the pantropic strain CB/05, whereas dogs in group C were used as negative controls. Clinical, post-mortem and virological investigations showed that, despite the high serum antibody titres induced by the prior natural infection with enteric CCoV, dogs were susceptible to experimental infection with strain CB/05. This was shown by the occurrence of faecal shedding, and dogs displaying moderate clinical signs, mainly vomiting and diarrhoea. Involvement of the lymphoid tissues was evident as demonstrated by the acute lymphopenia (below 70% of the initial counts), gross lesions in spleen and lymph nodes and detection of CB/05 RNA in thymus, spleen and lymph nodes of some infected dogs. The presence of viral RNA in lymphoid tissues was observed only in dogs euthanised in the early stages of infection and the clinical course of the infection was unrelated to the viral dose administered. The present study demonstrates that strain CB/05 is able to induce infection and disease in dogs seropositive to enteric CCoV, thus highlighting the need for extensive epidemiological investigation and for the possible development of novel antigenically relevant vaccines.
has issue date	2010-01-08(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2009.10.077
bibo:pmid	19887130
has license	els-covid
sha1sum (hex)	ea4f8b48b70c782f7698c4991e9db7344443c0b5
schema:url	https://doi.org/10.1016/j.vaccine.2009.10.077
resource representing a document's title	Immunity after natural exposure to enteric canine coronavirus does not provide complete protection against infection with the new pantropic CB/05 strain
has PubMed Central identifier	PMC7115391
has PubMed identifier	19887130
schema:publication	Vaccine
resource representing a document's body	covid:ea4f8b48b70c782f7698c4991e9db7344443c0b5#body_text
is schema:about of	named entity 'The presence' named entity 'dogs' named entity 'demonstrated' named entity 'groups' named entity 'negative' named entity 'vomiting' named entity 'evidence' named entity 'IMMUNITY' named entity 'INITIAL' named entity 'FATAL' named entity 'THYMUS' named entity 'COUNTS' named entity 'LYMPHOPENIA' named entity 'POST-MORTEM' named entity 'VIRAL' named entity 'EPIDEMIOLOGICAL' named entity 'NATURAL INFECTION' named entity 'GROSS LESIONS' named entity 'LYMPH NODES' named entity 'RECENT' named entity 'USED' named entity 'PRIOR' named entity 'VIROLOGICAL' named entity 'CLINICAL' named entity 'INVOLVEMENT' named entity 'DEVELOPMENT' named entity 'REPORTED' named entity 'LYMPHOID TISSUES' named entity 'OUTBREAK' named entity 'SHEDDING' named entity 'NEED FOR' named entity 'DOGS' named entity 'DISPLAYING' named entity 'OCCURRENCE' named entity 'SEROPOSITIVE' named entity 'DOSES' named entity 'PROVIDE' named entity 'CANINE CORONAVIRUS' named entity 'EXPOSURE TO' named entity 'DETECTION' named entity 'SERUM' named entity 'VACCINES' named entity 'INFECTION' named entity '70%' named entity 'ANTIBODY TITRES' named entity 'NATURAL' named entity 'PROVIDED' named entity 'RNA' named entity 'INDUCED' named entity 'OBSERVED' named entity 'DISTRIBUTED' named entity 'STRAIN' named entity 'EXPERIMENTAL INFECTION' named entity 'NEGATIVE' named entity 'DEMONSTRATED' named entity 'MODERATE' named entity 'DISEASE' named entity 'VIRAL RNA' named entity 'INDUCE' named entity 'INVESTIGATIONS' covid:arg/ea4f8b48b70c782f7698c4991e9db7344443c0b5 named entity 'BEAGLES' named entity 'DIFFERENT' named entity 'INVESTIGATION' named entity 'CONTROL GROUP' named entity 'ENTERIC' named entity 'NATURAL' named entity 'NEW' named entity 'PROTECTION' named entity 'FAECAL' named entity 'EXPOSURE TO'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software