About: Prognostic value of myocardial fibrosis on cardiac MRI in patients with ischemic cardiomyopathy, a systematic review

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About: Prognostic value of myocardial fibrosis on cardiac MRI in patients with ischemic cardiomyopathy, a systematic review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prognostic value of myocardial fibrosis on cardiac MRI in patients with ischemic cardiomyopathy, a systematic review
Creator	Lopes, Renato Al-Khatib, Sana Patel, Manesh Chery, Godefroy Kamp, Nicholas Kosinski, Andrzej Al-Khatib, Gillian, Sanders Lopes, Manesh Patel, Sana Schmidler, Schmidler, Renato
Source	Elsevier; PMC
abstract	The use of cardiac magnetic resonance imaging (c-MRI) in risk stratification for clinical outcomes of patients with ischemic cardiomyopathy (ICM) remains low. OBJECTIVES: This systematic review investigated the prognostic value of myocardial fibrosis as assessed by late gadolinium enhancement (LGE) on c-MRI in patients with ICM for ventricular tachyarrhythmia, sudden cardiac death (SCD), or all-cause mortality. METHODS: We conducted a systematic review of the electronic databases Pubmed and Embase for relevant prospective English-language studies published between January 1990 and February 2019. All included articles were prospective studies that comprised of human participants greater than 18 years old with ischemic cardiomyopathy (ICM) and a primary or secondary prevention ICD, had a sample size >30 participants, had at least 6 months follow-up, and reported on ventricular tachyarrhythmia, SCD and all-cause mortality. A total of 90 articles related to ICM were identified and were subsequently screened independently by two authors. Pooled sensitivity and specificity of LGE were calculated using random-effects model. RESULTS: Eight studies with 1085 participants were included in the final analysis. The mean age of patients varied from 43–83 years, with most patients being men. The most common comorbidities reported included history of diabetes mellitus (22–62%), hyperlipidemia (40–86%), and hypertension (35–88%). The ejection fraction of each study was reported as mean or median, and varied from 22–35%. During a follow-up that ranged from 8.5 to 65 months, there were 110 ventricular arrhythmic events reported. The pooled sensitivity and specificity of LGE for ICD therapy delivered for ventricular arrhythmias were 0.79 (95% Cl: 0.66–0.87) and 0.28 (95% Cl: 0.14–0.46) respectively. For all-cause mortality, the pooled sensitivity and specificity of LGE were 0.76 (95% Cl: 0.40–0.93) and 0.41 (95% Cl: 0.14–0.75) respectively. While SCD was of significant interest to our review, only one of the studies reported on the association between LGE and SCD leading to the subsequent exclusion of SCD from the endpoint analysis. CONCLUSION: LGE has high prognostic value in predicting adverse outcomes in patients with ICM and may provide helpful information for clinical decision-making related to SCD prevention. Our findings illustrate how LGE may improve current risk stratification, prognostication and selection of patients with ICM for ICD therapy.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.1016/j.ahj.2020.08.004
has license	no-cc
sha1sum (hex)	ea5a5ff2f04b2de191de59ea373aa09d3d31c3d5
schema:url	https://doi.org/10.1016/j.ahj.2020.08.004
resource representing a document's title	Prognostic value of myocardial fibrosis on cardiac MRI in patients with ischemic cardiomyopathy, a systematic review
has PubMed Central identifier	PMC7417269
schema:publication	Am Heart J
resource representing a document's body	covid:ea5a5ff2f04b2de191de59ea373aa09d3d31c3d5#body_text
is schema:about of	named entity 'ICM' named entity 'Journal' named entity 'Prognostic' named entity 'systematic review' named entity 'fibrosis' named entity 'LOW' named entity 'cardiac magnetic resonance' named entity 'Word counts' named entity 'MRI' named entity 'clinical outcomes' named entity 'myocardial fibrosis' named entity 'systematic review' named entity 'ventricular tachyarrhythmia' named entity 'myocardial fibrosis' named entity 'hyperlipidemia' named entity '8.5' named entity 'risk stratification' named entity 'Pubmed' named entity 'secondary endpoints' named entity 'systolic dysfunction' named entity 'scar' named entity 'imaging modality' named entity 'fibrosis' named entity 'co-morbid' named entity 'ventricular tachyarrhythmias' named entity 'ICM' named entity 'cardiac magnetic resonance imaging' named entity 'scar' named entity 'clinical outcomes' named entity 'scar' named entity 'ICD' named entity 'scar' named entity 'ICD' named entity 'sudden cardiac death' named entity 'prognosis' named entity 'scar' named entity 'myocardial infarct' named entity 'sensitivities and specificities' named entity 'scar' named entity 'MRI' named entity 'ARB' named entity 'scar' named entity 'infarct' named entity 're-entry' named entity 'follow-up' named entity 'risk factors' named entity 'implantable cardioverter defibrillator' named entity 'ICD' named entity 'metafor' named entity 'MRI' named entity 'ventricular arrhythmias' named entity 'MRI' named entity 'secondary prevention' named entity 'ICD' named entity 'scar' named entity 'death, sudden' named entity 'electrophysiology study' named entity 'all-cause mortality' named entity 'SCD' named entity 'angiotensin receptor blockers' named entity 'Heterogeneity' named entity 'contrast agents' named entity 'defibrillator' named entity 'tachycardia' named entity 'scar' named entity 'tachycardia' named entity 'tachycardia, ventricular' named entity 'ICM' named entity 'hypertension' named entity 'myocardial scar' named entity 'systematic review' named entity 'all-cause mortality'

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