About: Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease

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About: Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease
Creator	White, David Birnbaum, Brian Girish Shirali, · Goudar, Suma Gross-Toalson, Jami Malloy-Walton, Lindsey Panchangam, Chaitanya Parthiban, Anitha Reid, Kimberly
source	PMC
abstract	Children and adolescents with cardiac disease (CCD) have significant morbidity and lower quality of life. However, there are no broadly applicable tools similar to the frailty score as described in the elderly, to define functional phenotype in terms of physical capability and psychosocial wellbeing in CCD. The purpose of this study is to investigate the domains of the frailty in CCD. We prospectively recruited CCD (8–17.5 years old, 70% single ventricle, 27% heart failure, 12% pulmonary hypertension; NYHA classes I, II and III) and age and gender matched healthy controls (total n = 56; CCD n = 34, controls n = 22; age 12.6 ± 2.6 years; 39.3% female). We measured the five domains of frailty: slowness, weakness, exhaustion, body composition and physical activity using developmentally appropriate methods. Age and gender-based population norms were used to obtain Z scores and percentiles for each measurement. Two-tailed t-tests were used to compare the two groups. The CCD group performed significantly worse in all five domains of frailty compared to healthy controls. Slowness: 6-min walk test with Z score −3.9 ± 1.3 vs −1.4 ± 1.3, p < 0.001; weakness: handgrip strength percentile 18.9 ± 20.9 vs 57.9 ± 26.0, p < 0.001; exhaustion: multidimensional fatigue scale percentile 63.7 ± 13.5 vs 83.3 ± 14.4, p < 0.001; body composition: height percentile 43.4 ± 29.5 vs 71.4 ± 25.2, p < 0.001, weight percentile 46.0 ± 36.0 vs 70.9 ± 24.3, p = 0.006, BMI percentile 48.4 ± 35.5 vs 66.9 ± 24.2, p = 0.04, triceps skinfold thickness 41.0 ± 24.0 vs 54.4 ± 22.1, p = 0.04; physical activity: pediatric activity questionnaire score 2 ± 0.6 vs 2.7 ± 0.6, p < 0.001. The domains of frailty can be quantified in children using developmentally appropriate methods. CCD differ significantly from controls in all five domains, supporting the concept of quantifying the domains of frailty. Larger longitudinal studies are needed to study frailty in CCD and examine if it predicts adverse health outcomes. Clinical Trial Registration: The ClinicalTrials.gov identification number is NCT02999438. https://clinicaltrials.gov/ct2/show/NCT02999438.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.1007/s00246-020-02354-7
bibo:pmid	32377892
has license	no-cc
sha1sum (hex)	ea74098f7f42604711cfc50692a1df493152a1ff
schema:url	https://doi.org/10.1007/s00246-020-02354-7
resource representing a document's title	Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease
has PubMed Central identifier	PMC7223568
has PubMed identifier	32377892
schema:publication	Pediatr Cardiol
resource representing a document's body	covid:ea74098f7f42604711cfc50692a1df493152a1ff#body_text
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