About: Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
Creator	Weber, Friedemann Reguera, Juan Carlos De La Torre, Juan Ois Ferron, Franç
Source	Elsevier; Medline; PMC
abstract	Abstract Bunyaviridae and Arenaviridae virus families include an important number of highly pathogenic viruses for humans. They are enveloped viruses with negative stranded RNA genomes divided into three (bunyaviruses) or two (arenaviruses) segments. Each genome segment is coated by the viral nucleoproteins (NPs) and the polymerase (L protein) to form a functional ribonucleoprotein (RNP) complex. The viral RNP provides the necessary context on which the L protein carries out the biosynthetic processes of RNA replication and gene transcription. Decades of research have provided a good understanding of the molecular processes underlying RNA synthesis, both RNA replication and gene transcription, for these two families of viruses. In this review we will provide a global view of the common features, as well as differences, of the molecular biology of Bunyaviridae and Arenaviridae. We will also describe structures of protein and protein-RNA complexes so far determined for these viral families, mainly focusing on the L protein, and discuss their implications for understanding the mechanisms of viral RNA replication and gene transcription within the architecture of viral RNPs, also taking into account the cellular context in which these processes occur. Finally, we will discuss the implications of these structural findings for the development of antiviral drugs to treat human diseases caused by members of the Bunyaviridae and Arenaviridae families.
has issue date	2017-04-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2017.01.018
bibo:pmid	28137457
has license	els-covid
sha1sum (hex)	ea894263c04eed5c8b0f1ca55f3177e4d4f608b4
schema:url	https://doi.org/10.1016/j.virusres.2017.01.018
resource representing a document's title	Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
has PubMed Central identifier	PMC7114536
has PubMed identifier	28137457
schema:publication	Virus Research
resource representing a document's body	covid:ea894263c04eed5c8b0f1ca55f3177e4d4f608b4#body_text
is schema:about of	named entity 'MECHANISMS' named entity 'context' named entity 'Bunyaviridae' named entity 'viral' named entity 'polymerase' named entity 'Arenaviridae' named entity 'REPLICATION' named entity 'TAKING' named entity 'DEVELOPMENT' named entity 'STRUCTURES' named entity 'TO FORM' named entity 'POLYMERASE' named entity 'UNDERLYING' named entity 'FINDINGS' named entity 'COMPLEX' named entity 'MEMBERS' named entity 'MOLECULAR BIOLOGY' named entity 'ARCHITECTURE' named entity 'THEIR' named entity 'CELLULAR CONTEXT' named entity 'BIOSYNTHETIC' named entity 'CARRIES' named entity 'BUNYAVIRIDAE' named entity 'FUNCTIONAL' named entity 'MOLECULAR' named entity 'PROVIDES' named entity 'OCCUR' named entity 'NEGATIVE' named entity 'TREAT' named entity 'PROVIDE' named entity 'BUNYAVIRIDAE' named entity 'VIRUS' named entity 'GLOBAL' named entity 'TRANSCRIPTION' named entity 'ARENAVIRIDAE' named entity 'PROTEINS' named entity 'COMPLEXES' named entity 'FEATURES' named entity 'MECHANISMS' named entity 'FAR' named entity 'SEGMENTS' named entity 'STRUCTURAL' named entity 'DESCRIBE' named entity 'DIVIDED' named entity 'PATHOGENIC' named entity 'RNA SYNTHESIS' named entity 'HAVE' named entity 'UNDERSTANDING' named entity 'THESE' named entity 'RNPS' named entity 'PROTEIN' named entity 'DISCUSS' named entity 'HUMANS' named entity 'FAMILIES' named entity 'NECESSARY' named entity 'INCLUDE' named entity 'SEGMENT' named entity 'RNP' named entity 'HUMAN DISEASES' named entity 'PROTEIN ' named entity 'CAUSED BY' named entity 'VIRAL RNA' named entity 'FOCUSING' named entity 'GENOME' named entity 'HIGHLY' named entity 'VIRUSES' named entity 'ACCOUNT' named entity 'VIEW' named entity 'PROCESSES' named entity 'NUMBER OF' named entity 'RNA REPLICATION' named entity 'CONTEXT' named entity 'RNA' named entity 'GOOD' named entity 'DETERMINED' named entity 'VIRAL' named entity 'ANTIVIRAL DRUGS' named entity 'ARENAVIRIDAE'

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