About: The transcriptomic response to viral infection of two strains of shrimp (Litopenaeus vannamei)

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About: The transcriptomic response to viral infection of two strains of shrimp (Litopenaeus vannamei) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The transcriptomic response to viral infection of two strains of shrimp (Litopenaeus vannamei)
Creator	Veloso, Artur Browdy, Craig Chapman, Robert Warr, Gregory
Source	Elsevier; Medline; PMC
abstract	Abstract The extent to which data-intensive studies of the transcriptome can provide insight into biological responses is not well defined, especially in the case of species (such as shrimp) where much physiological and biochemical knowledge is missing. In this study we took a transcriptomic approach to gain insight into the response to viral infection of two strains of the Pacific whiteleg shrimp (Litopenaeus vannamei) that differ in their resistance to Taura Syndrome Virus (TSV). Changes in gene expression in the hepatopancreas following infection with TSV and Yellow Head Virus (YHV) were assessed using a cDNA microarray containing 2469 putative unigenes. The null hypothesis tested was that significant differences between the transcriptomic responses to viral infection of resistant and sensitive strains would not be detected. This hypothesis was broadly rejected, with the most surprising observation being that the baseline (control, unchallenged) sensitive and resistant strains expressed distinguishable transcriptomic signatures. The resistant line was pre-disposed to lower expression of genes encoding viral (and host) proteins. Many of the genes differentiating resistant and sensitive lines are involved in protein metabolism, cellular trafficking, immune defense and stress response, although it was not possible to clearly identify candidate genes responsible for TSV resistance. In contrast to TSV challenge, YSV either failed to perturb the host transcriptome or created a “confused” response that was difficult to interpret.
has issue date	2011-03-31(xsd:dateTime)
bibo:doi	10.1016/j.dci.2010.10.001
bibo:pmid	20955731
has license	els-covid
sha1sum (hex)	eb0b73f2b5a3a098c7e4107e50b48cb9111705dd
schema:url	https://doi.org/10.1016/j.dci.2010.10.001
resource representing a document's title	The transcriptomic response to viral infection of two strains of shrimp (Litopenaeus vannamei)
has PubMed Central identifier	PMC7103212
has PubMed identifier	20955731
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:eb0b73f2b5a3a098c7e4107e50b48cb9111705dd#body_text
is schema:about of	named entity 'STRAINS' named entity 'Pacific' named entity 'species' named entity 'responsible' named entity 'encoding' named entity 'created' named entity 'TSV' named entity 'insight' named entity 'Taura Syndrome Virus' named entity 'viral infection' named entity 'FOLLOWING' named entity 'HYPOTHESIS' named entity 'KNOWLEDGE' named entity 'DEFENSE' named entity 'RESISTANCE' named entity 'EXPRESSED' named entity 'SIGNIFICANT' named entity 'INVOLVED' named entity 'PROVIDE' named entity 'LINE' named entity 'MISSING' named entity 'INTERPRET' named entity 'WHERE' named entity 'RESPONSE TO' named entity 'SENSITIVE' named entity 'NOT WELL' named entity 'USING' named entity 'HEPATOPANCREAS' named entity 'TRAFFICKING' named entity 'STRAINS' named entity 'PROTEIN METABOLISM' named entity 'CASE' named entity 'TESTED' named entity 'RESPONSES' named entity 'APPROACH' named entity 'EITHER' named entity 'IDENTIFY' named entity 'INFECTION' named entity 'PHYSIOLOGICAL AND BIOCHEMICAL' named entity 'MUCH' named entity 'VIRAL INFECTION' named entity 'CONTAINING' named entity 'CREATED' named entity 'PRE' named entity 'LINES' named entity 'CHALLENGE' named entity 'RESISTANCE TO' named entity 'GAIN' named entity 'FAILED' named entity 'REJECTED' named entity 'EXPRESSION' named entity 'CANDIDATE GENES' named entity 'HOST' named entity 'VIRAL' named entity 'POSSIBLE' named entity 'VIRAL INFECTION' named entity 'SHRIMP' named entity 'STUDY' named entity 'GENES' named entity 'SIGNATURES' named entity 'STUDIES' named entity 'STRESS RESPONSE' named entity 'ENCODING' named entity 'CHANGES' named entity 'CDNA MICROARRAY' named entity 'DIFFERENTIATING' named entity 'DIFFICULT' named entity 'CELLULAR' named entity 'RESISTANT' named entity 'TSV' named entity 'WELL DEFINED' named entity 'YELLOW HEAD VIRUS' named entity 'NULL HYPOTHESIS' named entity 'RESPONSIBLE' named entity 'BIOLOGICAL' named entity 'BEING' named entity 'EXTENT' named entity 'OBSERVATION'

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