About: Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
Creator	Fan, Jie Ji, Jing-Jing
Source	PMC
abstract	The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer.
has issue date	2019-10-25(xsd:dateTime)
bibo:doi	10.1186/s40779-019-0222-9
bibo:pmid	31651369
has license	cc-by
sha1sum (hex)	eb133d6301554c7c8715363002f304e6ee08301d
schema:url	https://doi.org/10.1186/s40779-019-0222-9
resource representing a document's title	Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
has PubMed Central identifier	PMC6814050
has PubMed identifier	31651369
schema:publication	Mil Med Res
resource representing a document's body	covid:eb133d6301554c7c8715363002f304e6ee08301d#body_text
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