About: Viral and host determinants of RNA virus vector replication and expression

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral and host determinants of RNA virus vector replication and expression
Creator	Ahlquist, Paul Chen, Jianbo Hao, Linhui Kushner, David Schwartz, Michael Dye, Billy
Source	Elsevier; Medline; PMC
abstract	Abstract Positive-strand RNA viruses have proven to be valuable vectors for delivery and expression of antigens for direct vaccination of animals and vaccine production in plants. However, optimal use of these viruses as vectors for vaccine and other purposes is limited by incomplete understanding of their replication pathways and associated constraints on inserted foreign genes. Further insights into RNA virus vector design and optimization are emerging from recent advances on the function of viral RNA replication factors, the nature of the viral RNA replication complex as a membrane-bounded compartment sequestering replication components from competing processes and host defenses, and identification of surprisingly diverse host genes contributing to many virus replication steps.
has issue date	2005-03-07(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2004.11.005
bibo:pmid	15734041
has license	els-covid
sha1sum (hex)	eb23de72150266c463b52e1719fdc5bd591756fe
schema:url	https://doi.org/10.1016/j.vaccine.2004.11.005
resource representing a document's title	Viral and host determinants of RNA virus vector replication and expression
has PubMed Central identifier	PMC7115378
has PubMed identifier	15734041
schema:publication	Vaccine
resource representing a document's body	covid:eb23de72150266c463b52e1719fdc5bd591756fe#body_text
is schema:about of	named entity 'HOST' named entity 'vectors' named entity 'vaccine' named entity 'replication' named entity 'expression' named entity 'RNA' named entity 'replication' named entity 'USE OF' named entity 'VIRUS REPLICATION' named entity 'COMPONENTS' named entity 'VIRUSES' named entity 'COMPLEX' named entity 'REPLICATION' named entity 'OPTIMAL' named entity 'STRAND' named entity 'FUNCTION' named entity 'RNA REPLICATION' named entity 'ANTIGENS' named entity 'ASSOCIATED' named entity 'HOST' named entity 'RNA VIRUS' named entity 'PROVEN' named entity 'VIRUS VECTOR' named entity 'MEMBRANE' named entity 'LIMITED BY' named entity 'UNDERSTANDING' named entity 'INSERTED' named entity 'INCOMPLETE' named entity 'DIRECT' named entity 'STEPS' named entity 'BOUNDED' named entity 'VACCINE' named entity 'EXPRESSION' named entity 'CONTRIBUTING' named entity 'DIVERSE' named entity 'PATHWAYS' named entity 'RNA VIRUS' named entity 'ANIMALS' named entity 'THESE' named entity 'RNA VIRUSES' named entity 'DESIGN' named entity 'SEQUESTERING' named entity 'VECTORS' named entity 'VACCINATION' named entity 'THEIR' named entity 'VIRUS VECTOR' named entity 'DETERMINANTS' named entity 'FOREIGN' named entity 'COMPARTMENT' named entity 'PLANTS' named entity 'POSITIVE' named entity 'OPTIMIZATION' named entity 'DELIVERY' named entity 'VACCINE PRODUCTION' named entity 'INSIGHTS' named entity 'HAVE' named entity 'GENES' named entity 'IDENTIFICATION' named entity 'PURPOSES' named entity 'NATURE' named entity 'VIRAL AND' named entity 'REPLICATION' named entity 'EXPRESSION' named entity 'PROCESSES' named entity 'RECENT' named entity 'VIRAL RNA' covid:arg/eb23de72150266c463b52e1719fdc5bd591756fe named entity 'vector' named entity 'optimal' named entity 'identification' named entity 'viruses' named entity 'nature' named entity 'defenses' named entity 'viral RNA replication' named entity 'viral RNA replication' named entity 'host defenses'

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