About: Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report

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About: Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report
Creator	Urita, Yoshihisa Arai, Chiaki Fuchinoue, Yutaka Hamai, Asami Iwasaki, Yasuo Kano, Osamu Kasahara, Mizuki Kido, Hidenori Masuda, Hiroyuki Nemoto, Masaaki Sadamoto, Sota Shibuya, Kazutoshi Shiraga, Nobuyuki Suzuki, Kenichi Tai, Toshihiro Takahashi, Yukitoshi Takeda, Teppei Wakayama, Megumi Yamabe, Fumihito
Source	Medline; PMC
abstract	BACKGROUND: Kikuchi-Fujimoto disease is a self-limited clinicopathologic entity that is increasingly recognized worldwide. Kikuchi-Fujimoto disease is characterized by cervical lymphadenopathy occurring in young adults. Neurologic involvement is rare, and testitis directly caused by Kikuchi-Fujimoto disease has not yet been reported. CASE PRESENTATION: A 19-year-old man was brought to our clinic with complaints of fever, headache, fatigue, and left lower quadrant pain that had persisted for 3 weeks. On physical examination, painful cervical lymphadenopathies were observed. Meningitis was suspected based on a cerebrospinal fluid examination, and left-sided orchitis was diagnosed based on findings from magnetic resonance imaging and ultrasonography. However, neither antibiotics nor antiviral drugs were effective in treating the patient’s symptoms. On the 20(th) day of hospitalization, the patient experienced a loss of consciousness, and brain T2-weighted magnetic resonance imaging showed asymmetrical, high-signal intensities in both basal nuclei and the left temporal lobe. Encephalitis was suspected, and the patient was treated with intravenous prednisolone pulse therapy (1 g/day) for 3 days and intravenous immunoglobulin therapy for 5 days. A left cervical lymph node biopsy showed apoptotic necrosis in paracortical and cortical areas with an abundance of macrophages and large lymphoid cells, which had irregular nuclei suggestive of Kikuchi-Fujimoto disease; the pathological findings from a brain biopsy were the same as those of the cervical lymph node biopsy. The encephalitis and cervical lymphadenopathies followed a benign course, as did the testitis. CONCLUSIONS: This is the first report of Kikuchi-Fujimoto disease involving painful testitis and pathologically proven asymmetrical brain regions. Kikuchi-Fujimoto disease should be included in the differential diagnosis when a patient presents with encephalitis, testitis, and fever of unknown origin.
has issue date	2017-02-01(xsd:dateTime)
bibo:doi	10.1186/s12883-017-0807-4
bibo:pmid	28143446
has license	cc-by
sha1sum (hex)	eb657ff6a2abb31f6e8c6c9ac91814cb8fcda133
schema:url	https://doi.org/10.1186/s12883-017-0807-4
resource representing a document's title	Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report
has PubMed Central identifier	PMC5286801
has PubMed identifier	28143446
schema:publication	BMC Neurol
resource representing a document's body	covid:eb657ff6a2abb31f6e8c6c9ac91814cb8fcda133#body_text
is schema:about of	named entity 'KIKUCHI-FUJIMOTO DISEASE' named entity 'brain' named entity 'asymmetrical' named entity 'suspected' named entity 'Neurologic' named entity 'experienced' named entity 'headache' named entity 'temporal lobe' named entity 'Kikuchi-Fujimoto disease' named entity 'macrophages' named entity 'based' named entity 'cervical lymph node' named entity 'patient' named entity 'large' named entity 'consciousness' named entity 'lymphadenitis' named entity 'WORLDWIDE' named entity 'DIAGNOSED' covid:arg/eb657ff6a2abb31f6e8c6c9ac91814cb8fcda133 named entity '27S' named entity 'INCLUDED' named entity 'LYMPHOID CELLS' named entity 'SUGGESTIVE OF' named entity 'INTRAVENOUS' named entity 'CERVICAL LYMPHADENOPATHY' named entity 'LEFT TEMPORAL LOBE' named entity 'ABUNDANCE' named entity 'YOUNG ADULTS' named entity 'MENINGITIS' named entity 'REPORT' named entity 'INTRAVENOUS IMMUNOGLOBULIN THERAPY' named entity 'CERVICAL' named entity 'ENTITY' named entity 'COURSE' named entity 'NEUROLOGIC INVOLVEMENT IS RARE' named entity 'OUR' named entity 'HEADACHE' named entity 'ANTIBIOTICS' named entity 'CLINIC' named entity 'FATIGUE' named entity 'PATIENT' named entity 'LEFT LOWER QUADRANT PAIN' named entity 'TESTITIS' named entity 'ENCEPHALITIS' named entity 'FEVER OF UNKNOWN ORIGIN' named entity 'CASE PRESENTATION' named entity 'EFFECTIVE' named entity 'IS A' named entity 'FINDINGS' named entity 'SUSPECTED' named entity 'COMPLAINTS' named entity 'INVOLVING' named entity 'PREDNISOLONE' named entity 'SAME AS' named entity 'CASE REPORT' named entity 'NECROTIZING LYMPHADENITIS' named entity 'PAINFUL' named entity 'ULTRASONOGRAPHY' named entity 'HIGH' named entity 'OBSERVED' named entity 'MAN' named entity 'EXPERIENCED' named entity '3 WEEKS'

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