About: Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China

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About: Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China
Creator	Hu, Rongliang Zhang, Fei Zhang, Shoufeng Velasco-Villa, Andres Liu, Ye Rupprecht, Charles Hou, Yanli Wu, Xianfu Zhao, Jinghui
Source	Medline; PMC
abstract	BACKGROUND: The frequent occurrence of ferret badger-associated human rabies cases in southeast China highlights the lack of laboratory-based surveillance and urges revisiting the potential importance of this animal in rabies transmission. To determine if the ferret badgers actually contribute to human and dog rabies cases, and the possible origin of the ferret badger-associated rabies in the region, an active rabies survey was conducted to determine the frequency of rabies infection and seroprevalence in dogs and ferret badgers. METHODS: A retrospective survey on rabies epidemics was performed in Zhejiang, Jiangxi and Anhui provinces in southeast China. The brain tissues from ferret badgers and dogs were assayed by fluorescent antibody test. Rabies virus was isolated and sequenced for phylogenetic analysis. The sera from ferret badgers and dogs were titrated using rabies virus neutralizing antibodies (VNA) test. RESULTS: The ferret badgers presented a higher percentage of rabies seroconversion than dogs did in the endemic region, reaching a maximum of 95% in the collected samples. Nine ferret badger-associated rabies viruses were isolated, sequenced, and were phylogenetically clustered as a separate group. Nucleotide sequence revealed 99.4-99.8% homology within the ferret badger isolates, and 83-89% homology to the dog isolates in the nucleoprotein and glycoprotein genes in the same rabies endemic regions. CONCLUSIONS: Our data suggest ferret badger-associated rabies has likely formed as an independent enzootic originating from dogs during the long-term rabies infestation in southeast China. The eventual role of FB rabies in public health remains unclear. However, management of ferret badger bites, rabies awareness and control in the related regions should be an immediate need.
has issue date	2010-08-06(xsd:dateTime)
bibo:doi	10.1186/1471-2334-10-234
bibo:pmid	20691095
has license	cc-by
sha1sum (hex)	eb6bcd87e93e2bac6bd7b03367102b0a05e458e3
schema:url	https://doi.org/10.1186/1471-2334-10-234
resource representing a document's title	Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China
has PubMed Central identifier	PMC2927599
has PubMed identifier	20691095
schema:publication	BMC Infect Dis
resource representing a document's body	covid:eb6bcd87e93e2bac6bd7b03367102b0a05e458e3#body_text
is schema:about of	named entity 'Zhejiang' named entity 'Rabies virus' named entity 'ITS' named entity 'POTENTIAL' named entity 'SOUTHEAST' named entity 'BACKGROUND' named entity 'TEST' named entity 'FLUORESCENT ANTIBODY' named entity 'CASES' named entity 'RABIES' named entity 'DOG' named entity 'METHODS' named entity 'EPIDEMICS' named entity 'BADGERS' named entity 'SOUTHEAST' named entity 'ISOLATED' named entity 'ANTIBODY TEST' named entity 'CHINA' named entity 'ORIGIN' named entity 'SERA' named entity 'INFECTION' named entity 'CONTRIBUTE ' named entity 'ORIGIN' named entity 'NEUTRALIZING ANTIBODIES' named entity 'LABORATORY' named entity 'HUMAN' named entity 'BASED' named entity 'TRANSMISSION' named entity 'TRANSMISSION' named entity 'CHINA' named entity 'SOURCE' named entity 'POSSIBLE' named entity 'SEROPREVALENCE' named entity 'RETROSPECTIVE' named entity 'REGION' named entity 'DOGS' named entity 'THE BRAIN' named entity 'BRAIN TISSUES' named entity 'ASSOCIATED' named entity 'SURVEILLANCE' named entity 'HUMAN RABIES' named entity 'PERFORMED' named entity 'FERRET BADGER' named entity 'FERRET' named entity 'DETERMINE' named entity 'LACK' named entity 'SURVEY' named entity 'FREQUENCY' named entity 'OCCURRENCE' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RABIES' named entity 'ACTIVE' named entity 'USING' named entity 'ANIMAL' named entity 'FERRET BADGER' named entity 'FREQUENT' named entity 'RABIES VIRUS' named entity 'POTENTIAL' covid:arg/eb6bcd87e93e2bac6bd7b03367102b0a05e458e3 named entity 'titrated' named entity 'rabies' named entity 'survey' named entity 'determine' named entity 'badgers' named entity 'human' named entity 'VNA' named entity 'rabies' named entity 'China' named entity 'rabies' named entity 'China' named entity 'neutralizing antibodies' named entity 'ferret' named entity 'rabies'

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