About: DDESC: Dragon database for exploration of sodium channels in human

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About: DDESC: Dragon database for exploration of sodium channels in human Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DDESC: Dragon database for exploration of sodium channels in human
Creator	Kaur, Mandeep Sagar, Sunil Christoffels, Alan Dawe, Adam Radovanovic, Aleksandar Schaefer, Ulf Bajic, Vladimir Seshadri, Vijayaraghava
Source	Medline; PMC
abstract	BACKGROUND: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. RESULTS: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as %22genes and proteins%22, %22metabolites and enzymes%22, %22toxins%22, %22chemicals with pharmacological effects%22, %22disease concepts%22, %22human anatomy%22, %22pathways and pathway reactions%22 and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. CONCLUSION: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web .
has issue date	2008-12-20(xsd:dateTime)
bibo:doi	10.1186/1471-2164-9-622
bibo:pmid	19099596
has license	cc-by
sha1sum (hex)	eb824213356f63dbaabe4c3f454914e24d6e6a71
schema:url	https://doi.org/10.1186/1471-2164-9-622
resource representing a document's title	DDESC: Dragon database for exploration of sodium channels in human
has PubMed Central identifier	PMC2631582
has PubMed identifier	19099596
schema:publication	BMC Genomics
resource representing a document's body	covid:eb824213356f63dbaabe4c3f454914e24d6e6a71#body_text
is schema:about of	named entity 'ion' named entity 'genes' named entity 'sodium channel' named entity 'GENOMICS' named entity 'SUPERFAMILY' named entity 'DATABASE' named entity 'INTEGRAL MEMBRANE PROTEINS' named entity 'SODIUM CHANNELS' named entity 'BRUGADA SYNDROME' named entity 'BACKGROUND' named entity 'RESOURCE' named entity 'FEBRILE' named entity 'HUMAN' named entity 'THESE' named entity 'GENETIC DISORDERS' named entity 'AVAILABLE' named entity 'DRAGON' named entity 'SODIUM CHANNELS' named entity 'EXPLORATION' named entity 'BMC' named entity 'VENTRICULAR FIBRILLATION' named entity 'SODIUM CHANNEL' named entity 'EPILEPSY' named entity 'HAVE' named entity 'LONG QT SYNDROME' named entity 'INSENSITIVITY TO PAIN' named entity 'HUMAN HEALTH' named entity 'CHANNELOPATHY' named entity 'SUPPORT' named entity 'SIGNIFICANT' named entity 'ENCODING' named entity 'EFFECTS' named entity 'FOCUSED' named entity 'INFORMATION' named entity 'ION CHANNELS' named entity 'MUTATIONS' named entity 'ASSOCIATED' named entity 'GENES' named entity 'INHERITED GENETIC' named entity 'PROTEINS' named entity 'RELATED' named entity 'EXPLORATION' named entity 'focused' named entity 'epilepsy' named entity 'membrane proteins' named entity 'sodium channels' named entity 'superfamily' named entity 'insensitivity to pain' named entity 'integral membrane proteins' named entity 'Brugada syndrome' named entity 'Sodium channels' named entity 'drug design' named entity 'correlation' named entity 'gene' named entity 'biological entities' named entity 'VOLTAGE-GATED POTASSIUM CHANNEL' named entity 'ion channel' named entity 'complement' named entity 'febrile' named entity 'SCN1A' named entity 'voltage-gated sodium channels' named entity 'metabolites' named entity 'co-occurrence' named entity 'SCN1A' named entity 'DDOC' named entity 'SCN1A' named entity 'sodium channels' named entity 'sodium channel' named entity 'PubMed' named entity 'human anatomy' named entity '1.1' named entity 'sodium' named entity 'F-measure' named entity 'guanine nucleotide exchange factor'

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