About: Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties

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About: Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties
Creator	Deluca, Hector Kutuzova, Galina
source	Elsevier; Medline; PMC
abstract	Abstract Microarray technology has been used to discover 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) induced gene expression changes in rat small intestine in vivo. Here, we report gene expression changes related to intestinal absorption or transport, the immune system and angiogenesis in response to 1,25-(OH)2D3. Vitamin D deficient rats were intrajugularly given vehicle or vehicle containing 730ng of 1,25-(OH)2D3/kg of body weight. Intestinal mRNA was harvested from duodenal mucosa at 15min, 1, 3, and 6h post-injection and studied by Affymetrix microarrays. Genes significantly affected by 1,25-(OH)2D3 were confirmed by quantitative RT-PCR with remarkable agreement. The most strongly affected gene in intestine was CYP24 with 97-fold increase at 6h post-1,25-(OH)2D3 treatment. Intestinal calcium absorption genes: TRPV5, TRPV6, calbindin D9k, and Ca2+ dependent ATPase all were up-regulated in response to 1,25-(OH)2D3, supporting the currently accepted mechanism of 1,25-(OH)2D3 induced transcellular calcium transport. However, a 1,25-(OH)2D3 suppression of several intra-/intercellular matrix modeling proteins such as sodium/potassium ATPase, claudin 3, aquaporin 8, cadherin 17, and RhoA suggests a vitamin D regulation of tight junction permeability and paracellular calcium transport. Several other genes related to the immune system and angiogenesis whose expression was changed in response to 1,25-(OH)2D3 provided evidence for an immunomodulatory and anti-angiogenic role of 1,25-(OH)2D3.
has issue date	2004-12-15(xsd:dateTime)
bibo:doi	10.1016/j.abb.2004.09.004
bibo:pmid	15542054
has license	els-covid
sha1sum (hex)	eb8fd1687558675ae897364349cfdb7cff603ea9
schema:url	https://doi.org/10.1016/j.abb.2004.09.004
resource representing a document's title	Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties
has PubMed Central identifier	PMC7172970
has PubMed identifier	15542054
schema:publication	Archives of Biochemistry and Biophysics
resource representing a document's body	covid:eb8fd1687558675ae897364349cfdb7cff603ea9#body_text
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