About: In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus
Creator	Pringproa, Kidsadagon Arjin, Chaiwat Hongsibsong, Surat Mekchay, Supamit Ruksiriwanich, Warintorn Seel-Audom, Mintra Sringarm, Korawan
Source	Medline; PMC
abstract	BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) results in economic losses in the swine industry globally. Several studies have investigated the use of plant extracts in the prevention and control of PRRS outbreaks. Thai medicinal plants may be useful for treating PRRSV infection in pigs. Therefore, we investigated the in vitro anti-PRRSV and antioxidant properties of seven Thai medicinal plants: Caesalpinia sappan Linn., Garcinia mangostana Linn., Houttuynia cordata, Perilla frutescens, Clinacanthus nutans, Phyllanthus emblica, and Tiliacora triandra. RESULTS: Using antiviral screening, we observed that T. triandra extract strongly inhibited PRRSV infectivity in MARC-145 cells [virus titer 3.5 median tissue culture infective dose (TCID(50))/ml (log10)] at 24 h post-infection, whereas C. sappan extract strongly inhibited PRRSV replication [virus titer 2.5 TCID(50)/ml (log10)] at 72 h post-infection. C. sappan extract had the highest total phenolic content [220.52 mM gallic acid equivalent/g] and lowest half-maximal inhibitory concentration [1.17 mg/ml in 2,2-diphenyl-1-picrylhydrazyl and 2.58 mg/ml in 2,2-azino-bis (3-ethylbenzothiazo-line-6-sulfonic acid) diammonium salt]. CONCLUSION: T. triandra extract could inhibit PRRSV infectivity, whereas C. sappan extract was the most effective in inhibiting PRRSV replication in MARC-145 cells. This study elucidates the antiviral activities of Thai medicinal plant extracts in vivo. The results promise that Thai medicinal plant extracts, particularly T. triandra and C. sappan extracts, can be developed into pharmaceutical drugs for the prevention of PRRS in pigs.
has issue date	2020-03-30(xsd:dateTime)
bibo:doi	10.1186/s12917-020-02320-8
bibo:pmid	32228582
has license	cc-by
sha1sum (hex)	ebd636b9010a654fd014c59e5515ff50a1abad8d
schema:url	https://doi.org/10.1186/s12917-020-02320-8
resource representing a document's title	In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC7106583
has PubMed identifier	32228582
schema:publication	BMC Vet Res
resource representing a document's body	covid:ebd636b9010a654fd014c59e5515ff50a1abad8d#body_text
is schema:about of	named entity 'virus' named entity 'losses' named entity 'plant' named entity 'Therefore' named entity 'MEDICINAL PLANTS' covid:arg/ebd636b9010a654fd014c59e5515ff50a1abad8d named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'BACKGROUND' named entity 'HAVE' named entity 'PRRS' named entity 'PRRSV' named entity 'INFECTION' named entity 'GARCINIA MANGOSTANA' named entity 'GLOBALLY' named entity 'PREVENTION AND CONTROL' named entity 'CLINACANTHUS NUTANS' named entity 'HOUTTUYNIA CORDATA' named entity 'PLANT EXTRACTS' named entity 'ANTIOXIDANT' named entity 'LINN' named entity 'CAESALPINIA SAPPAN' named entity 'ECONOMIC' named entity 'SWINE' named entity 'SEVEN' named entity 'PIGS' named entity 'RESULTS' named entity 'USE OF' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'VIRUS' named entity 'PHYLLANTHUS EMBLICA' named entity 'USEFUL' named entity 'MEDICINAL PLANTS' named entity 'IN VITRO' named entity 'TREATING' named entity 'IN VITRO' named entity 'SCREENING' named entity 'ANTIVIRAL ACTIVITY' named entity 'CAUSED BY' named entity 'INVESTIGATED' named entity 'PROPERTIES' named entity 'PERILLA FRUTESCENS' named entity 'MAY BE' named entity 'INDUSTRY' named entity 'OUTBREAKS' named entity 'STUDIES' named entity 'THAI' named entity 'THAI' named entity 'TILIACORA TRIANDRA' named entity 'respiratory' named entity 'treating' named entity 'economic' named entity 'antiviral' named entity 'virus' named entity 'Porcine reproductive and respiratory syndrome' named entity 'antiviral activity' named entity 'antiviral' named entity 'formalin' named entity 'porcine reproductive and respiratory syndrome' named entity 'Ethanolic' named entity 'Switzerland' named entity 'genotype' named entity 'virus infection' named entity 'PRRSV' named entity 'phenolic content' named entity 'PRRSV' named entity '37°C' named entity 'antimicrobial agents' named entity 'viral pathogens' named entity 'Ethanol' named entity 'PRRSV' named entity 'antioxidant' named entity 'infection' named entity 'monoclonal antibody' named entity 'DMEM' named entity 'antiviral activity'

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