About: Neuropathologic features of four autopsied COVID‐19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neuropathologic features of four autopsied COVID‐19 patients
Creator	Vapalahti, Olli Kantele, Anu Kekäläinen, Eliisa Andersson, Noora Carpén, Olli Kantonen, Jonas Mahzabin, Shamita Myllykangas, Liisa Mäyränpää, Mikko Paetau, Anders Sajantila, Antti Tynninen, Olli
Source	Medline; PMC
abstract	Published descriptions of the neuropathological features of COVID‐19 patients have been controversial, ranging from only modest or no pathology to severe hypoxic and hemorrhagic phenotypes, thrombotic complications, acute disseminated encephalomyelitis‐like changes, and encephalitis and meningitis. Here we describe the neuropathological findings of four COVID‐19‐positive patients autopsied at the Helsinki University Hospital during the spring of 2020. While three of the patients (age range 63–90) exhibited merely mild to moderate hypoxia‐associated changes, one 38‐year‐old subject with obesity, diabetes (type 2), Parkinson’s disease, and a very severe clinical course was found to have severe ischemic injury, abundant microhemorrhages and enlarged perivascular spaces most pronounced in the white matter and deep gray matter. The pattern of ischemic changes suggested a defect in microcirculation. In addition, a few small perivascular white matter lesions, with macrophages engulfing myelin, were found. No signs of encephalitis or meningitis were detected in any of the patients. When conducting RT‐PCR and immunohistochemical analyses of brain tissue we could not demonstrate in any of the patients marked injury or presence of SARS‐CoV2 in the olfactory epithelium, olfactory bulbs, or brain areas responsible for respiratory control. In conclusion, our small autopsy series demonstrates various hypoxia‐associated neuropathological features in COVID‐19 patients, but no evidence of neurotropism or meningitis/encephalitis.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1111/bpa.12889
bibo:pmid	32762083
has license	no-cc
sha1sum (hex)	ebe120e89b78a9b23686f48294b5b99dcc08cb60
schema:url	https://doi.org/10.1111/bpa.12889
resource representing a document's title	Neuropathologic features of four autopsied COVID‐19 patients
has PubMed Central identifier	PMC7436498
has PubMed identifier	32762083
schema:publication	Brain Pathol
resource representing a document's body	covid:ebe120e89b78a9b23686f48294b5b99dcc08cb60#body_text
is schema:about of	named entity 'Helsinki University' named entity 'range' named entity 'defect' named entity 'mild' named entity 'patients' named entity 'DETECTED' named entity 'PATTERN' named entity 'DISEASE' named entity 'OBESITY' named entity 'SMALL' named entity 'BRAIN AREAS' named entity 'DESCRIBE' named entity 'ABUNDANT' named entity 'HAVE' named entity 'PATIENTS' named entity 'INJURY' named entity 'HERE' named entity 'PHENOTYPES' named entity 'MARKED' named entity 'OLFACTORY EPITHELIUM' covid:arg/ebe120e89b78a9b23686f48294b5b99dcc08cb60 named entity 'perivascular' named entity 'ranging' named entity 'lesions' named entity 'perivascular spaces' named entity 'microcirculation' named entity 'meningitis' named entity 'disease' named entity 'diabetes' named entity 'immunohistochemical' named entity 'ischemic injury' named entity 'respiratory' named entity 'hemorrhagic' named entity 'immunohistochemical' named entity 'brain tissue' named entity 'thrombotic complications' named entity 'perivascular' named entity 'acute disseminated encephalomyelitis' named entity 'encephalitis' named entity 'SARS-CoV2' named entity 'hypoxia' named entity 'patients' named entity 'comorbidities' named entity 'alpha-synuclein' named entity 'Department of Virology' named entity 'neuropathological' named entity 'Olfactory mucosa' named entity 'diabetes' named entity 'Helsinki University Hospital' named entity 'neuropathological' named entity 'Helsinki University Hospital' named entity 'encephalitis' named entity 'SARS-CoV2' named entity 'pathognomonic' named entity 'loose stools' named entity 'extracorporeal membrane oxygenation' named entity 'gray matter' named entity 'autopsies' named entity 'diabetes' named entity 'Helsinki University Hospital' named entity 'neurons' named entity 'neuropathological' named entity 'ADEM' named entity 'Finnish' named entity 'neurological symptoms' named entity 'brain stem' named entity 'Finnish' named entity 'edematous' named entity 'olfactory bulbs' named entity 'subendothelial'

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