About: Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity

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About: Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity
Creator	Farrar, Jeremy Le, Khanh De Jong, Menno Bryant, Juliet Anh, Lien Anh, Nguyen Cao, Ngoc Chi, Ho City, Minh Dac, Tran Dang, Huyen Do, Ha Ho, Lu Kim, Thi Le Binh, Bao Ly, Tu Ngo, Minh Nguyen, Bach Nguyen, Hai Nguyen, Minh Quang, Ngoc Rogier Van Doorn, H Thai, Quang Thanh, Thi Thu, Thi Tran, Anh Tran, Huong Tran, Loan Tran, Thu Trinh, Hong Trong, Ben Vietnam, Vo, Bao Vo, Thanh Ward,
Source	Medline; PMC
abstract	BACKGROUND: Despite a high burden of respiratory syncytial virus (RSV) infections among children, data on demographic and clinical characteristics of RSV are scarce in low and middle income countries. This study aims to describe the viral etiologies, the demographic, epidemiological, and clinical characteristics of children under two years of age who were hospitalized with a lower respiratory tract infections (LRTI), focusing on RSV (prevalence, seasonality, subgroups, viral load) and its association with disease severity. METHODS: A prospective study among children under two years of age, hospitalized with LRTI was conducted in two referral pediatric hospitals in Ho Chi Minh City, Vietnam, from May 2009 to December 2010. Socio-demographic, clinical data and nasopharyngeal swabs were collected on enrolment and discharge. Multiplex real-time RT-PCR (13 viruses) and quantitative RSV RT-PCR were used to identify viral pathogens, RSV load and subgroups. RESULTS: Among 632 cases, 48% were RSV positive. RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. In multivariate analysis, RV infection was significantly associated with severity while RSV infection was not. Among RSV infections, neither viral load nor viral co-infections were significantly associated with severity. Young age and having fever at admission were significantly associated with both RSV and LRTI severity. A shift in RSV subgroup predominance was observed during two consecutive rainy seasons but was not associated with severity. CONCLUSION: We report etiologies, the epidemiological and clinical characteristics of LRTI among hospitalized children under two years of age and risk factors of RSV and LRTI severity.
has issue date	2016-08-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0160606
bibo:pmid	27500954
has license	cc-by
sha1sum (hex)	ebf7e1110aa56a3066f9590befe475eb12b3eaa1
schema:url	https://doi.org/10.1371/journal.pone.0160606
resource representing a document's title	Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity
has PubMed Central identifier	PMC4976934
has PubMed identifier	27500954
schema:publication	PLoS One
resource representing a document's body	covid:ebf7e1110aa56a3066f9590befe475eb12b3eaa1#body_text
is schema:about of	named entity 'burden' named entity 'epidemiological' named entity 'viral load' named entity 'Infections' named entity 'Other' named entity 'Characteristics' covid:arg/ebf7e1110aa56a3066f9590befe475eb12b3eaa1 named entity 'prevalence' named entity 'seasonality' named entity '2010' named entity 'demographic' named entity 'RSV' named entity 'clinical characteristics' named entity 'co-infection' named entity 'viral load' named entity 'RSV' named entity 'nasal cannula' named entity 'intubation' named entity 'co-infection' named entity 'clinical diagnosis' named entity 'RSV' named entity 'LRTI' named entity 'N.A' named entity 'Spearman's rank correlation coefficient' named entity 'RSV' named entity 'Institutional Review Board' named entity 'expression profiles' named entity 'viruses' named entity 'antibiotics' named entity 'lower respiratory tract infections' named entity 'nasopharyngeal swabs' named entity 'MEDICAL STORY' named entity 'EnV' named entity 'goodness-of-fit test' named entity 'ROC' named entity 'etiologies' named entity 'metapneumovirus' named entity 'p-value' named entity 'nasopharyngeal swabs' named entity 'confounding factors' named entity 'LRTI' named entity 'viral infections' named entity 'LNA' named entity 'flu' named entity 'RSV' named entity 'viral infections' named entity 'CLINICAL CHARACTERISTICS'

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