About: Non-operative management for oral cavity carcinoma: definitive radiation therapy as a potential alternative treatment approach

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About: Non-operative management for oral cavity carcinoma: definitive radiation therapy as a potential alternative treatment approach Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-operative management for oral cavity carcinoma: definitive radiation therapy as a potential alternative treatment approach
Creator	Xu, Wei Gilbert, R Huang, Hui Kim, John Goldstein, J Huang, Shao Xu, S Chiu, K Bayley, Andrew Bayley, J Bratman, A Bratman, Scott Chepeha, Douglas Chepeha, I Chiu, Kevin Cho, John De Almeida, A De Almeida, John Gilbert, D Giuliani, J Giuliani, Meredith Goldstein, David Hope, Andrew Hope, D Hosni, A Hosni, Ali Huang, Jingyue Irish, Jonathan Monteiro, Eric O'sullivan, Brian Ringash, Jolie Spreafico, Anna Spreafico, J Sullivan, O Waldron, John Witterick, Ian Witterick, E
Source	Elsevier; PMC
abstract	PURPOSE: To determine the outcomes of oral cavity squamous cell cancer (OSCC) patients treated with non-surgical approach i.e. definitive intensity-modulated radiation therapy (IMRT). METHODS: All OSCC patients treated radically with IMRT (without primary surgery) between 2005-2014 were reviewed in a prospectively collected database. OSCC patients treated with definitive RT received concurrent chemotherapy except for early stage patients or those who declined or were unfit for chemotherapy. The 5-year local, and regional, distant control rates, disease-free, overall, and cancer-specific survival, and late toxicity were analyzed. RESULTS: Among 1316 OSCC patients treated with curative-intent; 108 patients (8%) received non-operative management due to: medical inoperability (n=14, 13%), surgical unresectability (n=8, 7%), patient declined surgery (n=15, 14%), attempted preservation of oral structure/function in view of required extensive surgery (n=53, 49%) or extensive oropharyngeal involvement (n=18, 17%). Sixty-eight (63%) were cT3-4, 38 (35%) were cN2-3, and 38 (35%) received concurrent chemotherapy. With a median follow-up of 52months, the 5-year local, regional, distant control rate, disease-free, overall, and cancer-specific survival were 78%, 92%, 90%, 42%, 50%, and 76% respectively. Patients with cN2-3 had higher rate of 5-year distant metastasis (24% vs 3%, p=0.001), with detrimental impact on DFS (p=0.03) and OS (p<0.02) on multivariable analysis. Grade ≥3 late toxicity was reported in 9% of patients (most common: grade 3 osteoradionecrosis in 6%). CONCLUSIONS: Non-operative management of OSCC resulted in a meaningful rate of locoregional control, and could be an alternative curative approach when primary surgery would be declined, unsuitable or unacceptably delayed.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1016/j.radonc.2020.08.013
has license	no-cc
sha1sum (hex)	ec6f46b53c4ac0165780c691da1f9748d5c3d80e
schema:url	https://doi.org/10.1016/j.radonc.2020.08.013
resource representing a document's title	Non-operative management for oral cavity carcinoma: definitive radiation therapy as a potential alternative treatment approach
has PubMed Central identifier	PMC7453211
schema:publication	Radiother Oncol
resource representing a document's body	covid:ec6f46b53c4ac0165780c691da1f9748d5c3d80e#body_text
is schema:about of	named entity 'management' named entity 'alternative' named entity 'https' named entity 'Oncology' named entity 'radiation therapy' named entity 'definitive' named entity 'oral cavity' named entity 'oral cavity' named entity 'Non-operative' named entity 'Non-operative' named entity 'carcinoma' named entity 'oropharyngeal' named entity 'subgroup analysis' named entity 'model selection' named entity 'metastases' named entity 'IMRT' named entity 'HNSCC' named entity 'oral cavity' named entity 'fractionation' named entity 'tumor' named entity 'chemotherapy' named entity 'OSCC' named entity 'fractionation' named entity 'IMRT' named entity 'median follow-up' named entity 'RCT' named entity 'IMRT' named entity 'OSCC' named entity 'endoscopic' named entity 'resection' named entity 'fractionation' named entity 'metastasis' named entity 'multivariable analysis' named entity 'chest X-ray' named entity 'MRI' named entity 'tumour control' named entity 'comorbidity' named entity 'disease-free' named entity 'N-categories' named entity 'OSCC' named entity 'toxicity' named entity 'advanced stage' named entity 'tumor' named entity 'malignancy' named entity 'chemotherapy' named entity 'OSCC' named entity 'chemotherapy'

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