About: Characteristics and outcomes of a cohort of SARS-CoV-2 patients in the Province of Reggio Emilia, Italy

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About: Characteristics and outcomes of a cohort of SARS-CoV-2 patients in the Province of Reggio Emilia, Italy Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characteristics and outcomes of a cohort of SARS-CoV-2 patients in the Province of Reggio Emilia, Italy
Creator	Rossi, Paolo Massari, Marco Salvarani, Carlo Besutti, Giulia Broccoli, Serena Costantini, Massimo Facciolongo, Nicola Ferrari, Anna Formoso, Giulio Grilli, Roberto Iotti, Valentina Marino, Massimiliano Pattacini, Pierpaolo Spaggiari, Lucia Vicentini, Massimo Bonelli, Efrem Canovi, Simone Colla, Rossana Fasano, Tommaso Lattuada, Ivana Nitrosi, Andrea Ottone, Marta Trabucco, Laura Albertazzi, Laura Bedeschi, Manuela Bellesia, Enrica Campari, Cinzia Corradini, Mattia Danelli, Giorgio De Pietri, Stefano Epidemiologist, Rossi Foracchia, Marco Formisano Statistician, Debora Formisano, Debora Gioia, Francesco Giorgi, Paolo Magnani, Elena Mancuso, Pamela Marino Statistician, Massimiliano Orsola, Bonanno Perilli, Cinzia Pilia, Annalisa Pinotti, Mirco Polese, Alessandra Revelli, Matteo Storchi Incerti, Silvia Venturelli Medical Doctor, Francesco Venturelli, Francesco Venturi, Ivano Vicentini Epidemiologist, Massimo Zaldini, Piera Zerbini, Alessandro
source	MedRxiv
abstract	Objectives. To describe the age- and sex-specific prevalence of SARS-CoV-2 disease (COVID-19) and its prognostic factors. Design. Population-based prospective cohort study on archive data. Setting. Preventive services and hospital care in the province of Reggio Emilia, Northern Italy. Participants. All 2653 symptomatic patients who tested positive for SARS-CoV-2 from February 27 to April 2, 2020 in the province of Reggio Emilia. Main outcome measures. Hospitalization and death up to April 2, 2020. Results. Females had higher prevalence of infection than males below age 50 (2.61 vs. 1.84 per 1000), but lower in older ages (16.49 vs. 20.86 per 1000 over age 80). Case fatality rate reached 20.7% (22/106) in cases with more than 4 weeks follow up. After adjusting for age and comorbidities, men had a higher risk of hospitalization (hazard ratio (HR) 1.4 95% confidence interval (95% CI) 1.2 to 1.6) and of death (HR 1.6, 95% CI 1.2 to 2.1). Patients over age 80 compared to < age 50 had HR 7.1 (95% CI 5.4 to 9.3) and HR 27.8 (95% CI 12.5 to 61.7) for hospitalization and death, respectively. Immigrants had a higher risk of hospitalization (HR 1.3, 95% CI 0.99 to 1.81) than Italians and a similar risk of death. Risk of hospitalization and of death were higher in patients with heart failure (HR 1.6, 95% CI 1.2 to 2.1and HR 2.3, 95% CI 1.6 to 3.2, respectively), arrhythmia (HR 1.5, 95% CI 1.2 to 1.9 and HR 1.8, 95% CI 1.3 to 2.5, respectively), dementia (HR 1.2, 95% CI 0.9 to 1.8 and HR 1.8, 95% CI 1.1 to 2.8, respectively), ischemic heart disease (HR 1.3, 95% CI 1.0 to 1.7 and HR 1.7, 95% CI 1.2 to 2.5, respectively), diabetes (HR 1.5, 95% CI 1.3 to 1.9 and HR 1.6, 95% CI 1.1 to 2.2, respectively), and hypertensions(HR 1.4, 95% CI 1.2 to 2.6 and HR 1.6, 95% CI 1.2 to 2.1, respectively), while COPD increased the risk of hospitalization (HR 1.9, 95% CI 1.4 to 2.5) but not of death (HR 1.1, 95% CI 0.7 to 1.7). Previous use of ACE inhibitors has no effect on risk of death (HR 0.97, 95% CI 0.69 to 1.34) Conclusions. The mechanisms underlying these associations are mostly unknown. A deeper understanding of the causal chain from infection, disease onset, and immune response to outcomes may explain how these prognostic factors act.
has issue date	2020-04-16(xsd:dateTime)
bibo:doi	10.1101/2020.04.13.20063545
has license	medrxiv
sha1sum (hex)	ec71ec52c877164c81a10b004b36a48b7059d4c9
schema:url	https://doi.org/10.1101/2020.04.13.20063545
resource representing a document's title	Characteristics and outcomes of a cohort of SARS-CoV-2 patients in the Province of Reggio Emilia, Italy
resource representing a document's body	covid:ec71ec52c877164c81a10b004b36a48b7059d4c9#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'health professionals' named entity 'province of Reggio Emilia' named entity 'medRxiv' named entity 'epidemic' named entity 'SARS-CoV-2' named entity 'ischemic heart disease' named entity 'epidemic' named entity 'CC-BY 4.0 International license' named entity 'medRxiv' named entity 'case fatality rates' named entity 'province of Reggio Emilia' named entity 'medRxiv' named entity 'infection' named entity 'comorbidities' named entity '3, 4' named entity 'preprint' named entity 'pharyngeal' named entity 'epidemic' named entity 'COPD' named entity 'general population' named entity 'case fatality rate' named entity 'preprint' named entity 'Ethics' named entity 'lockdown' named entity 'infection' named entity 'infection' named entity 'prognosis' named entity 'statistical analysis' named entity 'comorbidity' named entity 'Lombardy' named entity 'ischemic heart disease'

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