About: Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection

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About: Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection
Creator	Hassani, Shokoufeh Mirnia, Kayvan Afshani, Maryam Armin, & Maghsoudi, Salek Pouya, Maryam Seyyedeh, &
Source	Medline; PMC
abstract	OBJECTIVES: There are several types of research on the COVID-19 disease which have been conducting. It seems that prevailing over the pandemic would be achieved only by mastering over the virus pathophysiology. We tried to categorize the massive amount of available information for useful interpretation. EVIDENCE ACQUISITION: We searched databases with different keywords and search strategies that focus on virulence and pathophysiology of COVID-19. The present review has aimed to gather and categorize all implemented drugs based on the susceptible virulence mechanisms, and the pathophysiological events in the host cells, discussing and suggesting treatments. RESULTS: As a result, the COVID-19 lifecycle were categorized as following steps: “Host Cell Attachment” which is mainly conducted with ACE(2) receptors and TMPRSS2 from the host cell and Spike (S) protein, “Endocytosis Pathway” which is performed mainly by clathrin-mediated endocytosis, and “Viral Replication” which contains translation and replication of RNA viral genome. The virus pathogenicity is continued by “Inflammatory Reactions” which mainly caused moderate to severe COVID-19 disease. Besides, the possible effective therapeutics’ mechanism and the pharmaceutical agents that had at least one experience as a preclinical or clinical study on COVID-19 were clearly defined. CONCLUSION: The treatment protocol would be occasional based on the stage of the infection and the patient situation. The cocktail of medicines, which could affect almost all mentioned stages of COVID-19 disease, might be vital for patients with severe phenomena. GRAPHICAL ABSTRACT: [Figure: see text]
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1007/s40199-020-00359-4
bibo:pmid	32734518
has license	no-cc
sha1sum (hex)	ecb046c2539c2490d1b1b37d7f936fe278b2e6f1
schema:url	https://doi.org/10.1007/s40199-020-00359-4
resource representing a document's title	Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection
has PubMed Central identifier	PMC7391927
has PubMed identifier	32734518
schema:publication	Daru
resource representing a document's body	covid:ecb046c2539c2490d1b1b37d7f936fe278b2e6f1#body_text
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