About: Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation
Creator	Gambotto, Andrea Kim, Eun Erdos, Geza Huang, Shaohua Kenniston, Thomas Falo, Louis
Source	PMC
abstract	Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA). The immunogenicity of these two vaccines, named Ad5.ZIKV-Efl and ZIKV-rEfl, was tested in C57BL/6 mice. Prime/boost immunization regimen was associated with induction of a ZIKV-specific antibody response, which provided neutralizing immunity. Moreover, protection was evaluated in seven-day-old pups after virulent ZIKV intraperitoneal challenge. Pups born to mice immunized with Ad5.ZIKV-Efl were all protected against lethal challenge infection without weight loss or neurological signs, while pups born to dams immunized with MNA-ZIKV-rEfl were partially protected (50%). No protection was seen in pups born to phosphate buffered saline-immunized mice. This study illustrates the preliminary efficacy of the E ZIKV antigen vaccination in controlling ZIKV infectivity, providing a promising candidate vaccine and antigen format for the prevention of Zika virus disease.
has issue date	2016-10-03(xsd:dateTime)
bibo:doi	10.1016/j.ebiom.2016.09.028
bibo:pmid	27717627
has license	cc-by-nc-nd
sha1sum (hex)	ece140f2d510d370f594707b718066f7173a39e1
schema:url	https://doi.org/10.1016/j.ebiom.2016.09.028
resource representing a document's title	Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation
has PubMed Central identifier	PMC5264651
has PubMed identifier	27717627
schema:publication	EBioMedicine
resource representing a document's body	covid:ece140f2d510d370f594707b718066f7173a39e1#body_text
is schema:about of	named entity 'ADENOVIRAL' named entity 'PRIME' named entity 'ASSOCIATED WITH' named entity 'SEEN' named entity 'EFFICACY' named entity 'TRIMERIZATION' named entity 'TESTED' named entity 'LETHAL' named entity 'PRELIMINARY' named entity 'ASSOCIATION' named entity 'PARTIALLY' named entity 'STUDY' named entity 'VACCINE' named entity 'BASED' named entity 'INTRAPERITONEAL' named entity 'VACCINES' named entity 'INDUCTION' named entity 'GLOBAL' named entity 'EVALUATED' named entity 'ANTIGEN' named entity 'SEVEN-DAY' named entity 'IMMUNIZATION' named entity 'RAISED' named entity 'ZIKA' named entity 'promising' named entity 'neutralizing' named entity 'developed' named entity 'pups' named entity 'licenses' named entity 'PREVENTATIVE' named entity 'DAMS' named entity 'CHALLENGE' named entity 'VACCINATION' named entity 'SPECIFIC ANTIBODY' named entity 'PRELIMINARY EVALUATION' named entity 'ZIKA VIRUS' named entity 'LICENSE' named entity 'REGIMEN' named entity 'PROVIDED' named entity 'PREVENTION OF' named entity 'AD5' named entity 'ZIKA VIRUS' named entity 'CONTROLLING' named entity 'NUMBER OF' named entity 'MICROCEPHALY' named entity 'RISE' named entity 'INFECTION' named entity 'IMMUNITY' named entity '2015' named entity 'EXTRACELLULAR' named entity 'BRAZIL' named entity 'OUTBREAK' named entity 'VACCINES' named entity 'MOSQUITO' named entity 'IMMUNIZED' named entity 'BORN' named entity 'DUE TO' named entity 'PROTOTYPE' named entity 'SIGNIFICANT' named entity 'FORMAT' named entity 'SYNDROME' named entity 'BORNE' named entity 'DELIVERED' named entity 'NAMED' named entity 'INFECTIVITY' named entity 'DAY-OLD' named entity 'ORG' named entity 'SUBUNIT VACCINE' named entity 'FUSED TO' named entity 'SUBUNIT' named entity 'CARBOXYMETHYL CELLULOSE' named entity 'VIRULENT' named entity 'PHOSPHATE BUFFERED SALINE' named entity 'NC-' named entity 'C57BL' named entity 'PROVIDING'

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