About: Specific ACE2 Expression in Small Intestinal Enterocytes may Cause Gastrointestinal Symptoms and Injury after 2019-nCoV Infection

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Specific ACE2 Expression in Small Intestinal Enterocytes may Cause Gastrointestinal Symptoms and Injury after 2019-nCoV Infection
Creator	Li, Wei Zhang, Hui Li, Zhang Wu, Gang Dai, Lyu Dai, Zhi-Ming Lei, Lyu J-R Lei, Xiao-Ming Li, Hong-Bao Li, X-M Lyu, Jian-Rui Lyu, Jun
source	Elsevier; Medline; PMC
abstract	Abstract The coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China and rapidly spread in other countries in December 2019. The infected patients presented with fever, respiratory symptoms, sometimes with digestive and other systemic manifestations, and some progressed with a severe acute respiratory syndrome or even death. Associated digestive symptoms were frequently observed in the patients, with an unknown significance and mechanism. ACE2, as the major known functional receptor of the 2019 novel coronavirus (2019-nCoV) attracted our attention. We collected the clinical data of the 2019-nCoV-infected patients from published studies and extracted the data about the incidence of gastrointestinal symptoms. Furthermore, we used online datasets to analyze ACE2 expression in different human organs, especially in the small intestine, to explore the relationship between ACE2 expression patterns and clinical symptoms. We found that diarrhea accounted for a notable proportion of COVID-19 patients, ranging from 8.0% to 12.9%. The results reveal that ACE2 mRNA and protein are highly expressed in the small intestinal enterocytes but not in the goblet cells or intestinal immune cells. High expression of ACE2 on the surface cells in the digestive tract may lead to gastrointestinal symptoms and inflammation susceptibility. Overall, digestive symptoms were common in the COVID-19 patients. ACE2 expression on surface cells of the small intestine may mediate the invasion and amplification of the virus and activation of gastrointestinal inflammation. It is a possible mechanism of digestive symptoms in the COVID-19 patients and explains the presence of the virus in patients’ stool samples. The study also highlights the necessity of taking stool samples for suspected patients to help in early diagnosis and assessment of disease status.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.04.027
bibo:pmid	32311451
has license	els-covid
sha1sum (hex)	ecfc7e03c5ae929185123b1e77b8a9316e3ad728
schema:url	https://doi.org/10.1016/j.ijid.2020.04.027
resource representing a document's title	Specific ACE2 Expression in Small Intestinal Enterocytes may Cause Gastrointestinal Symptoms and Injury after 2019-nCoV Infection
has PubMed Central identifier	PMC7165079
has PubMed identifier	32311451
schema:publication	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
resource representing a document's body	covid:ecfc7e03c5ae929185123b1e77b8a9316e3ad728#body_text
is schema:about of	named entity 'SARS-CoV' named entity 'fecal-oral transmission' named entity 'possibility' named entity 'COVID-19' named entity 'SMALL INTESTINAL' named entity 'SMALL INTESTINE' covid:arg/ecfc7e03c5ae929185123b1e77b8a9316e3ad728 named entity 'alternative route' named entity '2019-nCoV' named entity 'Injury' named entity 'tissue tropism' named entity 'ACE2' named entity '2019-nCoV' named entity 'gene' named entity 'COVID' named entity '2019-nCoV' named entity 'Gastrointestinal Symptoms' named entity '2019-nCoV' named entity 'cohort studies' named entity 'COVID' named entity 'viral infection' named entity 'gastrointestinal symptoms' named entity 'RAS' named entity '2, 3' named entity 'SARS-CoV' named entity '2019-nCoV' named entity 'cell entry' named entity 'gastrointestinal tissues' named entity 'human tissues' named entity 'biopsies' named entity 'vomiting' named entity 'cholangiocytes' named entity 'endothelium' named entity 'cell types' named entity 'COVID' named entity 'anorexia' named entity 'cell receptor' named entity 'extrapulmonary' named entity 'wary' named entity 'Ang II' named entity 'molecule' named entity 'fever' named entity 'Human Protein Atlas' named entity 'titer' named entity 'scRNA-seq' named entity 'Human Protein Atlas' named entity 'virus' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'ACE2' named entity 'gastrointestinal symptoms' named entity 'coronavirus' named entity 'Severe Acute Respiratory Syndrome Coronavirus' named entity 'inflammation' named entity 'SARS-CoV' named entity 'enterocytes' named entity 'ACE2' named entity 'gene' named entity 'tropism' named entity 'respiratory tract' named entity 'RNA' named entity 'clinical evaluation' named entity 'SARS-CoV' named entity 'Gene expression' named entity 'ACE2' named entity 'ACE2' named entity 'amino acid' named entity 'fatigue' named entity 'virus' named entity 'receptor'

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