About: Establishment and Clinical Applications of a Portable System for Capturing Influenza Viruses Released through Coughing

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About: Establishment and Clinical Applications of a Portable System for Capturing Influenza Viruses Released through Coughing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Establishment and Clinical Applications of a Portable System for Capturing Influenza Viruses Released through Coughing
Creator	Nishimura, Hidekazu Yen, Hui-Ling Hatagishi, Etsuko Hori, Toru Miki, Hiroshi Morisaki, Yoshihisa Ohmiya, Suguru Okamoto, Michiko Saito, Reiko Saito, Wakana Sakata, Soichiro Shoji, Makoto Suzuki, Yasushi Yamamoto, Taro Yano, Hisakazu
Source	Medline; PMC
abstract	Coughing plays an important role in influenza transmission; however, there is insufficient information regarding the viral load in cough because of the lack of convenient and reliable collection methods. We developed a portable airborne particle-collection system to measure the viral load; it is equipped with an air sampler to draw air and pass it through a gelatin membrane filter connected to a cone-shaped, megaphone-like device to guide the cough airflow to the membrane. The membrane was dissolved in a medium, and the viral load was measured using quantitative real-time reverse transcriptase-polymerase chain reaction and a plaque assay. The approximate viral recovery rate of this system was 10% in simulation experiments to collect and quantify the viral particles aerosolized by a nebulizer. Using this system, cough samples were collected from 56 influenza A patients. The total viral detection rate was 41% (23/56), and the viral loads varied significantly (from <10, less than the detection limit, to 2240 viral gene copies/cough). Viable viruses were detected from 3 samples with ≤18 plaque forming units per cough sample. The virus detection rates were similar among different groups of patients infected with different viral subtypes and during different influenza seasons. Among patients who did not receive antiviral treatment, viruses were detected in one of six cases in the vaccinated group and four of six cases in the unvaccinated group. We found cases with high viral titers in throat swabs or oral secretions but very low or undetectable in coughs and vice versa suggesting other possible anatomical sites where the viruses might be mixed into the cough. Our system is easy to operate, appropriate for bedside use, and is useful for comparing the viral load in cough samples from influenza patients under various conditions and settings. However, further large-scale studies are warranted to validate our results.
has issue date	2014-08-01(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0103560
bibo:pmid	25083787
has license	cc-by
sha1sum (hex)	ed02cdbaaf52f191ad3bebb5a3bc117524718c8e
schema:url	https://doi.org/10.1371/journal.pone.0103560
resource representing a document's title	Establishment and Clinical Applications of a Portable System for Capturing Influenza Viruses Released through Coughing
has PubMed Central identifier	PMC4118893
has PubMed identifier	25083787
schema:publication	PLoS One
resource representing a document's body	covid:ed02cdbaaf52f191ad3bebb5a3bc117524718c8e#body_text
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