About: The central role of Fas‐ligand cell signaling in inflammatory lung diseases

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The central role of Fas‐ligand cell signaling in inflammatory lung diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The central role of Fas‐ligand cell signaling in inflammatory lung diseases
Creator	Borges, Valeria Dosreis, G Dosreis, George Zin, W
Source	Medline; PMC
abstract	Following inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas‐Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL‐1β and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas‐FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseases.
has issue date	2007-05-01(xsd:dateTime)
bibo:doi	10.1111/j.1582-4934.2004.tb00318.x
bibo:pmid	15491504
has license	no-cc
sha1sum (hex)	ed2b094531bb5c8b6cb5fcd4ca30650c3e9cae45
schema:url	https://doi.org/10.1111/j.1582-4934.2004.tb00318.x
resource representing a document's title	The central role of Fas‐ligand cell signaling in inflammatory lung diseases
has PubMed Central identifier	PMC6740074
has PubMed identifier	15491504
schema:publication	J Cell Mol Med
resource representing a document's body	covid:ed2b094531bb5c8b6cb5fcd4ca30650c3e9cae45#body_text
is schema:about of	named entity 'chemokine' named entity 'injury' named entity 'central' named entity 'Series' named entity 'CRITICAL' named entity 'BLOCKADE' named entity 'SIGNALING' named entity 'FOLLOWING' named entity 'BALANCE' named entity 'inflammation' named entity 'patients' named entity 'loss' named entity 'effective' named entity 'FasL' named entity 'proapoptotic' named entity 'transcription factors' named entity 'FasL' named entity 'cleavage' named entity 'TUNEL' named entity 'trimers' named entity 'vascular smooth muscle cells' named entity 'coal mining' named entity 'fibroblasts' named entity 'bronchiolar' named entity 'ALI' named entity 'apoptosis' named entity 'Serologic' named entity 'studies' named entity 'alveolar' named entity 'idiopathic pulmonary fibrosis' named entity 'interactions' named entity 'Apoptosis' named entity 'Serologic' named entity 'acute lung injury' named entity 'fibrosis' named entity 'Fas' named entity 'neutrophil' named entity 'cell signaling' named entity 'lung diseases' named entity 'Review Series' named entity 'macrophages' named entity 'sepsis' named entity 'FasL' named entity 'forkhead' named entity 'chemokines' named entity 'inflammation' named entity 'protein content' named entity 'silica' named entity 'pulmonary tuberculosis' named entity 'caspase-8' named entity 'alveolar epithelial cells' named entity 'Fas' named entity 'Fas' named entity 'Fas' named entity 'redox' named entity 'ligation' named entity 'FasL' named entity 'VSMC' named entity 'Soluble' named entity 'macrophages' named entity 'Fas' named entity 'DNA' named entity 'transcription factors' named entity 'chemokine' named entity 'inflammation' named entity 'IPF' named entity 'leukocyte' named entity 'tissue injury' named entity 'TUNEL' named entity 'cFLIP' named entity 'mice' named entity 'inflammatory mediators' named entity 'apoptosis' named entity 'p53' named entity 'antigens' named entity 'apoptosis' named entity 'FasL' named entity 'Fas'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software