About: COVID‐19 outbreak: The impact of stress on seizures in patients with epilepsy

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About: COVID‐19 outbreak: The impact of stress on seizures in patients with epilepsy Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID‐19 outbreak: The impact of stress on seizures in patients with epilepsy
Creator	Lu, Kai Li, Guo Furong, \| Huang, Shanshan Jia, Yuchao Suiqiang, Wang Wang, Furong Wu, Chunmei Yang, Yuyan Zhou, \|
source	Medline; PMC
abstract	OBJECTIVE: Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID‐19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. This study was designed to evaluate the influence of the COVID‐19 outbreak on seizures in PWE in the most severely affected area, Wuhan, and its surrounding cities. METHODS: In this single‐center, cross‐sectional study, PWE were surveyed via online questionnaires between February 23 and March 5, 2020. Collected data included demographic information, epilepsy‐related characteristics (seizure type, frequency, antiepileptic drugs [AEDs], and medication management), direct and perceived threat of COVID‐19, and changes in seizures during the outbreak. Psychological comorbidities were evaluated by the Patient Health Questionnaire–9, Generalized Anxiety Disorder–7 items, and Insomnia Severity Index (ISI). Multivariate logistic regression was used to identify precipitants for seizure exacerbation. RESULTS: We received 362 completed questionnaires after excluding 12 duplicates (response rate = 63.51%). A total of 31 (8.56%) patients had increased seizures during the outbreak. Exposure history to COVID‐19 (P = .001), uncontrolled seizure after AED therapy (P = .020), seizure frequency of two or more times per month before the outbreak (P = .005), change of AED regimen during the outbreak (AED reduction, withdrawal, replacement, skipping altogether; P = .002), and worry about the adverse effect of the outbreak on overall seizure‐related issues (severity = moderate to critical; P = .038) were risk factors for increased seizures. SIGNIFICANCE: A minority of PWE experienced seizure exacerbation during the outbreak of COVID‐19. Stress, uncontrolled seizures, and inappropriate change in AED regimen were associated with increased seizures. Based on these findings, stress might be an independent precipitant for triggering seizures in some PWE.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1111/epi.16635
bibo:pmid	32761900
has license	no-cc
sha1sum (hex)	ed5827dc26789600bf80ada4b78cc5d0b62c65b1
schema:url	https://doi.org/10.1111/epi.16635
resource representing a document's title	COVID‐19 outbreak: The impact of stress on seizures in patients with epilepsy
has PubMed Central identifier	PMC7436883
has PubMed identifier	32761900
schema:publication	Epilepsia
resource representing a document's body	covid:ed5827dc26789600bf80ada4b78cc5d0b62c65b1#body_text
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