About: Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis
Creator	Chang, J Hsu, T.-C Huang, H.-S Lee, C.-C Lin, S Tsai, C.-L
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: To provide a summary of evidence for the diagnostic accuracies of three multiplex PCR systems (mPCRs)—BioFire FilmArray RP (FilmArray), Nanosphere Verigene RV+ test (Verigene RV+) and Hologic Gen-Probe Prodesse assays—on the detection of viral respiratory infections. METHODS: A comprehensive search up to 1 July 2017 was conducted on Medline and Embase for studies that utilized FilmArray, Verigene RV+ and Prodesse for diagnosis of viral respiratory infections. A summary of diagnostic accuracies for the following five viruses were calculated: influenza A virus (FluA), influenza B virus, respiratory syncytial virus, human metapneumovirus and adenovirus. Hierarchical summary receiver operating curves were used for estimating the viral detection performance per assay. RESULTS: Twenty studies of 5510 patient samples were eligible for analysis. Multiplex PCRs demonstrated high diagnostic accuracy, with area under the receiver operating characteristic curve (AUROC) equal to or more than 0.98 for all the above viruses except for adenovirus (AUROC 0.89). FilmArray, Verigene RV+ and ProFlu+ (the only Prodesse assay with enough data) demonstrated a summary sensitivity for FluA of 0.911 (95% confidence interval, 0.848–0.949), 0.949 (95% confidence interval, 0.882–0.979) and 0.954 (95% confidence interval, 0.871–0.985), respectively. The three mPCRs were comparable in terms of detection of FluA. CONCLUSIONS: Point estimates calculated from eligible studies showed that the three mPCRs (FilmArray, Verigene RV+ and ProFlu+) are highly accurate and may provide important diagnostic information for early identification of respiratory virus infections. In patients with low pretest probability for FluA, these three mPCRs can predict a low possibility of infection and may justify withholding empirical antiviral treatments.
has issue date	2017-12-05(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2017.11.018
bibo:pmid	29208560
has license	no-cc
sha1sum (hex)	ed5c595aa5d503ef3250c066ef037926de1b2e64
schema:url	https://doi.org/10.1016/j.cmi.2017.11.018
resource representing a document's title	Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis
has PubMed Central identifier	PMC7128951
has PubMed identifier	29208560
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:ed5c595aa5d503ef3250c066ef037926de1b2e64#body_text
is schema:about of	named entity 'SYSTEMATIC REVIEW' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'Editor' named entity 'MULTIPLEX PCR' named entity 'META-ANALYSIS' named entity 'SYSTEM' named entity 'RAPID DIAGNOSIS' named entity 'EDITOR' covid:arg/ed5c595aa5d503ef3250c066ef037926de1b2e64 named entity 'Multiplex PCR' named entity 'Multiplex PCR' named entity 'systematic review' named entity 'virus infection' named entity 'emergency rooms' named entity 'infection' named entity 'ribavirin' named entity 'correlation' named entity 'rapid influenza diagnostic test' named entity 'United States' named entity 'pathogens' named entity 'supportive care' named entity 'ARIs' named entity 'FDA' named entity 'reference standard' named entity 'rapid diagnostic tests' named entity 'Gen-Probe' named entity 'significant difference' named entity 'adenovirus' named entity 'mortality rates' named entity 'chronic pulmonary disease' named entity 'influenza season' named entity 'diagnostic methods' named entity 'viruses' named entity 'statistical analysis' named entity 'pathogen' named entity 'virus' named entity 'melting curve analysis' named entity 'infection' named entity 'Diagnostic Accuracy' named entity 'FDA' named entity 'Reference Standard' named entity 'sensitivities and specificities' named entity 'clinical trials' named entity 'drug resistance' named entity 'traditional methods' named entity 'systematic reviews' named entity 'melting curve analysis' named entity 'virus infection' named entity 'real-time PCR' named entity 'FDA' named entity 'PubMed' named entity 'antibiotics' named entity 'viruses' named entity 'respiratory syncytial virus' named entity 'PCR' named entity 'Systematic Review' named entity 'diagnostic tests' named entity 'Reverse transcription' named entity 'sensitive and specific' named entity 'Gen-Probe' named entity 'sensitivity and specificity' named entity 'upper respiratory' named entity 'likelihood ratios' named entity 'meta-analysis' named entity 'pretest' named entity 'receiver operating characteristic' named entity 'Vienna' named entity 'lung' named entity 'Hologic' named entity 'hMPV' named entity 'viruses' named entity 'gold nanoparticle' named entity 'immunoassay' named entity 'viral pathogens' named entity 'Embase' named entity 'adenovirus'

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