About: Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

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About: Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo
Creator	Mukadi, Patrick Okitolonda-Wemakoy, Emile Sinai, Cyrus Lu, Kai Simmons, Graham Steffen, Imke Muyembe-Tamfum, Jean-Jacques Gadoth, Adva Ilunga-Kebela, Benoit Mossoko, Matthias Wasiswa, Joseph Williams, Russell Nicholson, Bradley Hoff, Nicole Rimoin, Anne Alfonso, Vivian Bramble, Matthew Doshi, Reena Spencer, Andre
Source	PMC
abstract	Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy499
bibo:pmid	30239838
has license	cc-by
sha1sum (hex)	ed8cb0477be53b0ffb5ebf65d4dd46453be053b2
schema:url	https://doi.org/10.1093/infdis/jiy499
resource representing a document's title	Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo
has PubMed Central identifier	PMC6350949
has PubMed identifier	30239838
schema:publication	J Infect Dis
resource representing a document's body	covid:ed8cb0477be53b0ffb5ebf65d4dd46453be053b2#body_text
is schema:about of	named entity 'HEALTHCARE WORKERS' named entity 'contact' named entity 'patients' named entity 'Ebola virus' named entity 'risk' named entity 'EBOV' named entity 'INFECTIOUS DISEASES' covid:arg/ed8cb0477be53b0ffb5ebf65d4dd46453be053b2 named entity 'GLYCOPROTEIN' named entity '234' named entity 'DETERMINE' named entity 'PROGRESSION' named entity 'CAPACITY' named entity 'ELEVATED' named entity 'IGG' named entity 'SAFETY PRECAUTIONS' named entity 'DEMONSTRATED' named entity 'DOCUMENTED' named entity 'COLLECTED' named entity 'SYMPTOMS' named entity 'PROPAGATION' named entity 'HAVE' named entity 'PLAYED' named entity 'ROLE' named entity 'OUTBREAKS' named entity 'MULTIPLE' named entity 'PRACTICED' named entity '282' named entity 'OUTBREAK' named entity 'CONTACT WITH' named entity 'EBOLA VIRUS' named entity 'POSITIVE' named entity 'DEMOCRATIC REPUBLIC OF THE CONGO' named entity 'ZONE' named entity 'SITE OF' named entity 'HIGHLIGHTING' named entity 'PROTEIN' named entity 'IMMUNOGLOBULIN G' named entity 'SETTINGS' named entity 'JOURNAL ' named entity 'EBOLAVIRUS' named entity 'ANTIGENS' named entity 'PATIENTS' named entity 'OVERALL' named entity 'SEROPREVALENCE' named entity 'INFECTION' named entity 'SIGNIFICANT' named entity 'EBOLA VIRUS DISEASE' named entity 'SERA' named entity 'SPECIMENS' named entity 'IMPORTANT' named entity 'INTERVIEWS' named entity 'PROPORTION' named entity 'ASPECT' named entity 'DEMOCRATIC REPUBLIC OF THE CONGO' named entity 'SEROLOGIC' named entity 'MARKERS' named entity 'NUCLEOPROTEIN' named entity 'THESE' named entity 'HEALTHCARE WORKERS' named entity 'HEALTHCARE' named entity 'HEALTH' named entity 'VIRUS'

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