About: Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia

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About: Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia
Creator	Abu-Asab, Mones Uhlenhaut, Christine Gubareva, Larisa Illei, Gabor Krogmann, Tammy Pavletic, Steven Cohen, Jeffrey Krause, Philip Carlos Gea-Banacloche, Juan Mcclenahan, Shasta
Source	Medline; PMC
abstract	A 38-year-old patient with systemic lupus erythematosus presented with pulmonary infiltrates and hypoxemia for several months following immunodepleting autologous hematopoietic stem cell transplantation. She was treated for influenza, which was isolated repeatedly from ororpharynx and bronchoalveolar lavage fluids, and later empirically for lupus pneumonitis, but expired 6 months after transplant. Autopsy findings failed to show influenza in the lungs or lupus pneumonitis. A novel generic PCR-based assay using degenerate primers identified human coronavirus HKU1 RNA in bronchoalveolar lavage fluid at autopsy. Coronavirus was confirmed by virus-specific PCRs of lung tissue at autopsy. Electron microscopy showed viral particles consistent with coronavirus HKU1 in lung tissue both at autopsy and from a previous biopsy. While human coronavirus HKU1 infection is not usually severe, in highly immunocompromised patients, it can be associated with fatal pneumonia.
has issue date	2011-07-12(xsd:dateTime)
bibo:doi	10.1111/j.1399-3062.2011.00657.x
bibo:pmid	21749586
has license	bronze-oa
sha1sum (hex)	ed8dc30f2ea9e692863a2b29954ab0028ce13a57
schema:url	https://doi.org/10.1111/j.1399-3062.2011.00657.x
resource representing a document's title	Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia
has PubMed Central identifier	PMC3416037
has PubMed identifier	21749586
schema:publication	Transplant Infectious Disease
resource representing a document's body	covid:ed8dc30f2ea9e692863a2b29954ab0028ce13a57#body_text
is schema:about of	named entity 'immunocompromised' named entity 'autologous hematopoietic stem cell transplantation' named entity 'lung' named entity 'generic' named entity 'highly' named entity 'viral' named entity 'HEMATOPOIETIC STEM CELL' named entity 'VIRAL PARTICLES' named entity 'BUT' named entity 'CORONAVIRUS HKU1' named entity 'PRESENTED' named entity 'SYSTEMIC LUPUS ERYTHEMATOSUS' named entity 'FAILED' named entity 'AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION' named entity 'BIOPSY' named entity 'SPECIFIC' named entity 'HUMAN CORONAVIRUS HKU1 RNA' named entity 'PREVIOUS' named entity 'NIH' named entity 'FLUIDS' named entity 'CORONAVIRUS' named entity 'HYPOXEMIA' named entity 'AUTOPSY' named entity 'TO IDENTIFY' named entity 'ACCESS' named entity 'THE LUNGS' named entity 'STEM CELL TRANSPLANT RECIPIENT' named entity 'CORONAVIRUS HKU1' named entity 'FATAL' named entity 'NOVEL' named entity 'PUBLIC' named entity 'PNEUMONIA' named entity 'USE OF' named entity 'VIRUS' named entity 'HIGHLY' named entity 'TREATED FOR' named entity 'CONSISTENT WITH' named entity 'PULMONARY INFILTRATES' named entity 'ASSAY' named entity 'ASSOCIATED WITH' named entity 'PNEUMONIA' named entity 'ASSAY' named entity 'DEGENERATE' named entity 'INFLUENZA' named entity 'THE LUNGS' named entity 'OLD' named entity 'TRANSPLANT' named entity 'ISOLATED' named entity 'VIRUS DETECTION' named entity 'USUALLY' named entity 'EXPIRED' named entity 'MONTHS' named entity 'FOLLOWING' named entity 'CONFIRMED BY' named entity 'PCR' named entity 'LUPUS PNEUMONITIS' named entity 'PATIENT' named entity 'INFECTION' named entity 'SEVERE' named entity 'ELECTRON MICROSCOPY' named entity 'FINDINGS' named entity 'USING' named entity 'YEAR' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'HUMAN CORONAVIRUS HKU1' named entity 'PRIMERS' named entity 'GENERIC' named entity 'NOVEL' named entity 'LUNG TISSUE' named entity 'BASED' named entity 'REPEATEDLY' named entity 'FATAL'

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