About: Pathological Changes in Masked Palm Civets Experimentally Infected by Severe Acute Respiratory Syndrome (SARS) Coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathological Changes in Masked Palm Civets Experimentally Infected by Severe Acute Respiratory Syndrome (SARS) Coronavirus
Creator	Guan, Y Liu, Y Tong, T Li, C Kong, X Liu, G Meng, Q Wang, L.-F Wang, M Wu, D Xiao, Y Yin, X
topic	covid:ed9f973784cad4c42001deddab29e9e68d7e4283#this
Source	Elsevier; Medline; PMC
abstract	Summary Masked palm civets are highly susceptible to infection with the severe acute respiratory syndrome coronavirus (SARS-CoV). Infected animals become less aggressive and develop pyrexia, lethargy and diarrhoea. The present study describes the spectrum of histopathological changes in the lung, spleen, lymph node, liver, small intestine, kidney and cerebrum of civets infected experimentally with SARS-CoV. In-situ hybridization (ISH) with probes specific for the RNA polymerase gene demonstrated viral RNA in the lung, small intestine and cerebrum only. In-situ labelling was employed in order to demonstrate cellular apoptosis in the cerebrum, but there was no evidence of apoptosis within the myocardium. These results indicate that SARS-CoV causes multi-organ pathology in civets, similar to that observed in human SARS patients. These parallels suggest that civets may be used as an animal model of this infection to gain insight into the pathogenesis of SARS and for evaluation of candidate vaccines and antiviral drugs.
has issue date	2008-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jcpa.2007.12.005
bibo:pmid	18343398
has license	els-covid
sha1sum (hex)	ed9f973784cad4c42001deddab29e9e68d7e4283
schema:url	https://doi.org/10.1016/j.jcpa.2007.12.005
resource representing a document's title	Pathological Changes in Masked Palm Civets Experimentally Infected by Severe Acute Respiratory Syndrome (SARS) Coronavirus
has PubMed Central identifier	PMC7094611
has PubMed identifier	18343398
schema:publication	Journal of Comparative Pathology
resource representing a document's body	covid:ed9f973784cad4c42001deddab29e9e68d7e4283#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ed9f973784cad4c42001deddab29e9e68d7e4283
is schema:about of	named entity 'civets' named entity 'vaccines' named entity 'develop' named entity 'pathogenesis' named entity 'demonstrate' named entity 'spleen' named entity 'Civets' named entity 'Infected' named entity 'CORONAVIRUS' named entity 'DEMONSTRATED' named entity 'OBSERVED' named entity 'SPECTRUM' named entity 'CEREBRUM' named entity 'PYREXIA' named entity 'LETHARGY' named entity 'INFECTED' named entity 'SIMILAR' named entity 'AGGRESSIVE' named entity 'PATHOLOGY' named entity 'USED' named entity 'PALM' named entity 'VIRAL RNA' named entity 'SPLEEN' named entity 'POLYMERASE GENE' named entity 'BUT' named entity 'PATIENTS' named entity 'CHANGES' named entity 'IN-SITU HYBRIDIZATION' named entity 'MASKED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'INFECTED' named entity 'CIVETS' named entity 'GAIN' named entity 'EVALUATION' named entity 'VACCINES' named entity 'PALM' named entity 'STUDY' named entity 'CHANGES' named entity 'PATHOLOGICAL' named entity 'CIVETS' named entity 'MYOCARDIUM' named entity 'DIARRHOEA' named entity 'SARS-COV' named entity 'MAY BE' named entity 'ANIMALS' named entity 'THESE' named entity 'SARS' named entity 'HUMAN' named entity 'CANDIDATE' named entity 'PRESENT' named entity 'PATHOGENESIS' named entity 'RNA POLYMERASE' named entity 'CELLULAR' named entity 'MULTI' named entity 'PROBES' named entity 'LIVER' named entity 'SUGGEST' named entity 'IN-SITU' named entity 'APOPTOSIS' named entity 'HIGHLY' named entity 'INSIGHT' named entity 'CAUSES' named entity 'KIDNEY' named entity 'SUSCEPTIBLE' named entity 'ORGAN' named entity 'LUNG' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'INFECTION'

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