About: Vesicular Transport of Progeny Parvovirus Particles through ER and Golgi Regulates Maturation and Cytolysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vesicular Transport of Progeny Parvovirus Particles through ER and Golgi Regulates Maturation and Cytolysis
Creator	Rommelaere, Jean Nü, P Rg, Jü Verine Bä, Sé
Source	PMC
abstract	Progeny particles of non-enveloped lytic parvoviruses were previously shown to be actively transported to the cell periphery through vesicles in a gelsolin-dependent manner. This process involves rearrangement and destruction of actin filaments, while microtubules become protected throughout the infection. Here the focus is on the intracellular egress pathway, as well as its impact on the properties and release of progeny virions. By colocalization with cellular marker proteins and specific modulation of the pathways through over-expression of variant effector genes transduced by recombinant adeno-associated virus vectors, we show that progeny PV particles become engulfed into COPII-vesicles in the endoplasmic reticulum (ER) and are transported through the Golgi to the plasma membrane. Besides known factors like sar1, sec24, rab1, the ERM family proteins, radixin and moesin play (an) essential role(s) in the formation/loading and targeting of virus-containing COPII-vesicles. These proteins also contribute to the transport through ER and Golgi of the well described analogue of cellular proteins, the secreted Gaussia luciferase in absence of virus infection. It is therefore likely that radixin and moesin also serve for a more general function in cellular exocytosis. Finally, parvovirus egress via ER and Golgi appears to be necessary for virions to gain full infectivity through post-assembly modifications (e.g. phosphorylation). While not being absolutely required for cytolysis and progeny virus release, vesicular transport of parvoviruses through ER and Golgi significantly accelerates these processes pointing to a regulatory role of this transport pathway.
has issue date	2013-09-19(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003605
bibo:pmid	24068925
has license	cc-by
sha1sum (hex)	ede3bef01a48a154a93f1286b907cd5a53a086eb
schema:url	https://doi.org/10.1371/journal.ppat.1003605
resource representing a document's title	Vesicular Transport of Progeny Parvovirus Particles through ER and Golgi Regulates Maturation and Cytolysis
has PubMed Central identifier	PMC3777860
has PubMed identifier	24068925
schema:publication	PLoS Pathog
resource representing a document's body	covid:ede3bef01a48a154a93f1286b907cd5a53a086eb#body_text
is schema:about of	named entity 'PROGENY' named entity 'HERE' named entity 'ACTIN FILAMENTS' named entity 'VARIANT' named entity 'VIRUS INFECTION' named entity 'PLASMA MEMBRANE' named entity 'RECOMBINANT ADENO-ASSOCIATED VIRUS' named entity 'TRANSPORT' named entity 'FOCUS' named entity 'LIKE' named entity 'GAIN' named entity 'VIRUS RELEASE' named entity 'VESICLES' named entity 'VIRIONS' named entity 'POINTING' named entity 'GENES' named entity 'EXOCYTOSIS' named entity 'INFECTIVITY' named entity 'ROLE' named entity 'MOESIN' named entity 'ENDOPLASMIC RETICULUM' named entity 'IMPACT' named entity 'ACCELERATES' named entity 'INTRACELLULAR' named entity 'MARKER' named entity 'REQUIRED' named entity 'COPII' named entity 'CONTAINING' named entity 'POST' named entity 'MICROTUBULES' named entity '28S' named entity 'ANALOGUE' named entity 'COLOCALIZATION' named entity 'CELLULAR' named entity 'PROPERTIES' named entity 'REARRANGEMENT' named entity 'INFECTION' named entity 'PATHWAY' named entity 'FORMATION' named entity 'PHOSPHORYLATION' named entity 'PLAY' named entity 'FAMILY' named entity 'PROCESS' named entity 'SEC24' named entity 'REGULATORY ROLE' named entity 'GOLGI' named entity 'DESCRIBED' named entity 'SPECIFIC' named entity 'PARVOVIRUS' named entity 'SERVE' named entity 'LYTIC' named entity 'CYTOLYSIS' named entity 'PROTEINS' named entity 'CONTRIBUTE ' named entity 'THE CELL' named entity 'THESE' named entity 'VIRUS' named entity 'PARVOVIRUSES' named entity 'BEING' named entity 'ESSENTIAL' named entity 'TARGETING' named entity 'GOLGI' named entity 'PARTICLES' named entity 'PARVOVIRUS' named entity 'GENERAL' named entity 'LIKELY' named entity 'ERM' named entity 'SECRETED' named entity 'ABSENCE OF' named entity 'DEPENDENT' named entity 'GAUSSIA LUCIFERASE' named entity 'RELEASE' named entity 'VECTORS' named entity 'EXPRESSION' named entity 'ASSEMBLY' named entity 'PATHWAYS' named entity 'KNOWN' named entity 'TRANSPORT PATHWAY'

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