About: Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination

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About: Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination
Creator	Mcfarland, Henry Mcfarlin, Dale Segal, Benjamin Voskuhl, Rhonda Raine, Cedric
topic	covid:ee2ffc76ba19f6d79314d5f8b48c918cd13a82df#this
Source	Elsevier; Medline; PMC
abstract	Abstract The discovery of T lymphocytes reactive to the peptide encoded by exon 2 of the myelin basic protein (MBP) gene in multiple sclerosis (MS) patients has drawn attention to MBP isoforms harboring that peptide as candidate autoantigens. Previously, immunological studies in MS had almost exclusively used the more abundant 18.5 kDa isoform of MBP, which does not does not contain the exon 2 peptide. Investigations of experimental allergic encephalomyelitis (EAE) have also focussed on the 18.5 kDa MBP isoform and its peptides. Since EAE is an animal model widely used widly used to study MS, we examined the encephalitogenic potential of exon 2 peptide in the SJL/J mouse. Evidence for increased expression of exon 2-containing isoforms during remyelination in mouse CNS suggested that exon 2-sensitized T cels, with encephalitogenic capacity, might be important in the pertuation of relapsing EAE (rEAE). Our experiments have demonstrated that exon 2 peptide is inherently immunogenic in SJL mice and that EAE could be induced by the adoptive transfer of exon 2-sensitized lymphocytes. Furthermore, the disease could be accentuated by the transfer of short-term exon 2-reactive lines or by a combination of adoptive transfer and antigenic challenge with exon 2 peptide. The immunodominant epitope(s) appeared to localize to the segment bordered by amino acids 59–85.
has issue date	1994-04-30(xsd:dateTime)
bibo:doi	10.1016/0165-5728(94)90123-6
bibo:pmid	7512579
has license	els-covid
sha1sum (hex)	ee2ffc76ba19f6d79314d5f8b48c918cd13a82df
schema:url	https://doi.org/10.1016/0165-5728%2894%2990123-6
resource representing a document's title	Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination
has PubMed Central identifier	PMC7119711
has PubMed identifier	7512579
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:ee2ffc76ba19f6d79314d5f8b48c918cd13a82df#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ee2ffc76ba19f6d79314d5f8b48c918cd13a82df
is schema:about of	named entity 'MBP GENE' named entity 'transfer' named entity 'peptide' named entity 'Our' named entity 'sensitized' named entity 'antigenic' named entity 'allergic' named entity 'PEPTIDE' named entity 'AUTOANTIGENS' named entity 'ISOFORMS' named entity 'REMYELINATION' named entity 'EXON' named entity 'USED' named entity 'STUDIES' named entity 'MIGHT BE' named entity 'DOES NOT' named entity 'LYMPHOCYTES' named entity 'ITS' named entity 'EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS' named entity 'HAVE' named entity 'EXON' named entity 'MULTIPLE SCLEROSIS' named entity 'INVESTIGATIONS' named entity 'STUDY' named entity 'OUR' named entity 'IMMUNOGENIC' named entity 'SJL' named entity 'T CELLS' named entity 'T LYMPHOCYTES' named entity '8.5' named entity 'POTENTIAL' named entity 'MYELIN BASIC PROTEIN' named entity 'CONTAINING' named entity 'ENCODED' named entity 'CNS' named entity 'PEPTIDES' named entity 'PROTEIN ' named entity 'DEMONSTRATED' named entity 'HARBORING' named entity 'EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS' named entity 'INDUCED' named entity 'REMYELINATION' named entity 'TRANSFER' named entity 'PEPTIDE' named entity 'CHALLENGE' named entity 'EXPERIMENTS' named entity 'ABUNDANT' named entity '28S' named entity 'EXAMINED' named entity 'CONTAIN' named entity '18.5' named entity 'ISOFORM' named entity 'IMMUNOLOGICAL' named entity 'ATTENTION' named entity 'EVIDENCE FOR' named entity 'ALMOST' named entity 'INCREASED EXPRESSION' named entity 'MOUSE' named entity 'CANDIDATE' named entity 'RELAPSING EAE' named entity 'PATIENTS' named entity 'EAE' named entity 'REACTIVE' named entity 'PREVIOUSLY' named entity 'ADOPTIVE TRANSFER' named entity 'MBP' named entity 'DISEASE' named entity 'AMINO ACIDS' named entity 'GENE' named entity 'INDUCED' named entity 'CAPACITY' named entity 'ENCODED' named entity 'TO LOCALIZE' named entity 'SHORT-TERM' named entity 'LYMPHOCYTES REACTIVE'

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