About: The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?
Creator	Casanova, Jean-Laurent Abel, Laurent
Source	Medline; PMC
abstract	Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria, archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by a tremendous diversity of microorganisms. Those that are large enough can even be infected by multicellular fungi and parasites. Each interaction is unique, if only because it operates between two unique living organisms, in an infinite diversity of circumstances. This is neatly illustrated by the extraordinarily high level of interindividual clinical variability in human infections, even for a given pathogen, ranging from a total absence of clinical manifestations to death. We discuss here the idea that the determinism of human life-threatening infectious diseases can be governed by single-gene inborn errors of immunity, which are rarely Mendelian and frequently display incomplete penetrance. We briefly review the evidence in support of this notion obtained over the last two decades, referring to a number of focused and thorough reviews published by eminent colleagues in this issue of Human Genetics. It seems that almost any life-threatening infectious disease can be driven by at least one, and, perhaps, a great many diverse monogenic inborn errors, which may nonetheless be immunologically related. While the proportions of monogenic cases remain unknown, a picture in which genetic heterogeneity is combined with physiological homogeneity is emerging from these studies. A preliminary sketch of the human genetic architecture of severe infectious diseases is perhaps in sight.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1007/s00439-020-02184-w
bibo:pmid	32462426
has license	no-cc
sha1sum (hex)	eeaed136becceb34453e02d505fc9c31f03bd684
schema:url	https://doi.org/10.1007/s00439-020-02184-w
resource representing a document's title	The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?
has PubMed Central identifier	PMC7251220
has PubMed identifier	32462426
schema:publication	Hum Genet
resource representing a document's body	covid:eeaed136becceb34453e02d505fc9c31f03bd684#body_text
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