About: Randomized controlled trial of the effect of regular paracetamol on influenza infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Randomized controlled trial of the effect of regular paracetamol on influenza infection
Creator	Siebers, Robert Jennings, Lance Beasley, Richard Braithwaite, Irene Weatherall, Mark Barrett, Kevin Blackmore, Timothy Jefferies, Sarah Luck, Michelle Perrin, Kyle Walker, Steven
source	Medline; PMC
abstract	BACKGROUND AND OBJECTIVE: Anti‐pyretic treatment is recommended in the management of influenza infection. In animal models anti‐pyretic treatment increases mortality from influenza. We investigated the effects of paracetamol on viral and clinical outcomes in adults with influenza infection. METHODS: This is a randomized, double‐blind, placebo‐controlled trial of adults aged 18–65 years with influenza‐like illness and positive influenza rapid antigen test. Treatments were 1 g paracetamol four times a day, or matching placebo, for 5 days. Pernasal swabs were taken for influenza quantitative RT‐PCR at Baseline and Days 1, 2 and 5. Temperature and symptom scores were recorded for 5–14 days or time of resolution respectively. The primary outcome variable was area under the curve (AUC) for quantitative PCR log(10) viral load from Baseline to Day 5. RESULTS: A total of 80 participants were randomized: no one was lost to follow up, and one withdrew after 4 days. There were 22 and 24 participants who were influenza PCR‐positive in placebo and in paracetamol groups respectively. Mean (SD) AUC PCR log(10) viral load was 4.40 (0.91) in placebo and 4.64 (0.88) in paracetamol; difference was −0.24, 95% CI: −0.78 to 0.29, P = 0.36. In all participants there were no differences in symptom scores, temperature, time to resolution of illness and health status, with no interaction between randomized treatment and whether influenza was detected by PCR. CONCLUSION: Regular paracetamol had no effect on viral shedding, temperature or clinical symptoms in patients with PCR‐confirmed influenza. There remains an insufficient evidence base for paracetamol use in influenza infection. Clinical trial registration: ACTRN12611000497909 at the Australian New Zealand Clinical Trials Registry.
has issue date	2015-12-06(xsd:dateTime)
bibo:doi	10.1111/resp.12685
bibo:pmid	26638130
has license	cc-by-nc
sha1sum (hex)	eecaac903d153e5b87e4ebdd289eb2615fffa0e4
schema:url	https://doi.org/10.1111/resp.12685
resource representing a document's title	Randomized controlled trial of the effect of regular paracetamol on influenza infection
has PubMed Central identifier	PMC4738455
has PubMed identifier	26638130
schema:publication	Respirology
resource representing a document's body	covid:eecaac903d153e5b87e4ebdd289eb2615fffa0e4#body_text
is schema:about of	named entity 'times' named entity 'Baseline' named entity 'Randomized controlled trial' named entity 'Methods' named entity 'variable' named entity 'placebo-controlled trial' named entity 'quantitative PCR' named entity 'Temperature' named entity 'randomized' named entity 'influenza' named entity 'placebo' named entity 'double-blind, placebo-controlled' named entity 'paracetamol' named entity 'influenza infection' named entity 'outcome variable' named entity 'PCR' named entity 'influenza' named entity 'paracetamol' named entity 'influenza infection' named entity 'cytokine' named entity 'community-acquired' named entity 'influenza' named entity 'odds ratio' named entity 'symptom' named entity 'PCR' named entity 'paracetamol' named entity 'PCR' named entity 'A-positive' named entity 'IFN-γ' named entity 'influenza' named entity 'adverse event' named entity 'NSAID' named entity 'influenza' named entity 'paracetamol' named entity 'A/H3N2' named entity 'influenza' named entity 'RNA' named entity 'clinical trials' named entity 'primary outcome measure' named entity 'parainfluenza' named entity 'human tissue' named entity 'PCR' named entity 'predictor variables' named entity 'influenza infection' named entity 'health status' named entity 'Paracetamol' named entity 'placebo' named entity 'paracetamol' named entity 'standard deviation' named entity 'asthma' named entity 'influenza' named entity 'sample size' named entity 'PCR' named entity 'placebo' named entity 'influenza-like illness' named entity 'symptom' named entity 'relative risks' named entity 'analysis of variance' named entity 'cytotoxic T lymphocytes' named entity 'influenza-like illness' named entity 'paracetamol' named entity 'cytokines' named entity 'influenza' named entity 'febrile' named entity 'human influenza' named entity 'Blood samples' named entity 'febrile' named entity 'polymerase chain reaction' named entity 'influenza infection' named entity 'influenza' named entity 'scatter plot'

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