About: Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19
Creator	Xu, Jin Jia, Ran Liu, • Wang, • Chang, Hailing Ge, Yanling Liang, • Hao Zhou, • Tian, • Zeng, •
Source	Medline; PMC
abstract	Children with Coronavirus Disease 2019 (COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. Therefore we initiated this study to figure out the features of immune response in children with COVID-19. Sera and whole blood cells from 19 children with COVID-19 during different phases after disease onset were collected. The cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon (IFN)-γ-induced protein 10 (IP10), interleukin (IL)-10 and IL-16. We observed an increase in T helper (Th)-2 cells and a suppression in regulatory T cells (Treg) in patients during acute phase, but no significant response was found in the IFN-γ-producing or tumor necrosis factor (TNF)-α-producing CD8(+ )T cells in patients. S-RBD and N IgM showed an early induction, while S-RBD and N IgG were prominently induced later in convalescent phase. Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4(+) T cell response and inactive CD8(+) T cell response, but their humoral immunity against SARS-CoV-2 were as strong as adults. Our finding presented immunological characteristics of children with COVID-19 and might give some clues as to why children develop less severe disease than adults.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1007/s12250-020-00265-8
bibo:pmid	32699972
has license	no-cc
sha1sum (hex)	ef024f02ba0d8cb06a27085661afd70975dd294a
schema:url	https://doi.org/10.1007/s12250-020-00265-8
resource representing a document's title	Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19
has PubMed Central identifier	PMC7373847
has PubMed identifier	32699972
schema:publication	Virol Sin
resource representing a document's body	covid:ef024f02ba0d8cb06a27085661afd70975dd294a#body_text
is schema:about of	named entity 'T cell' named entity 'study' named entity 'convalescent' named entity 'patients' named entity 'IgG' named entity 'phases' named entity 'elevation' named entity 'induction' named entity 'inflammatory' named entity 'Production' named entity 'EARLY' named entity 'INCLUDING' named entity 'RBD' named entity 'T HELPER' named entity 'CHARACTERISTICS' named entity 'PROTEIN ' named entity 'SYMPTOMS' named entity 'ANTIBODIES' covid:arg/ef024f02ba0d8cb06a27085661afd70975dd294a named entity 'prognosis' named entity 'T cell' named entity 'cytokine' named entity 'SARS-CoV-2' named entity 'phase' named entity 'symptoms' named entity 'Sera' named entity 'IgA' named entity 'sera' named entity 'SARS-CoV-2' named entity 'immune response' named entity 'TNF' named entity 'humoral immunity' named entity 'SARS-CoV-2' named entity 'IFN' named entity 'IgA' named entity 'IFN' named entity 'SARS-CoV-2' named entity 'tumor necrosis factor' named entity 'CD4' named entity 'IgE' named entity 'memory T cells' named entity 'IgM' named entity 'cytokine' named entity 'SARS-CoV-2' named entity 'Antibody' named entity 'chemokine' named entity 'IgG' named entity 'IL-16' named entity 'countries and territories' named entity 'IgA' named entity 'significant difference' named entity 'CD25' named entity 'Th2' named entity 'CRP' named entity 'virus' named entity 'secretion' named entity 'tissue destruction' named entity 'global health' named entity 'IgM' named entity 'IL-8' named entity 'CBA' named entity 'COVID' named entity 'IgA' named entity 'supplemental oxygen' named entity 'immune response' named entity 'chemokines' named entity 'virus infection' named entity 'protein' named entity 'staining' named entity 'cytokine' named entity 'IgA' named entity 'IgM'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software