About: Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway
Creator	Yang, Wei Jiang, Hong Cheng, Chao Feng, Zhaojun Liu, Chanmin Ma, Jieqiong Sun, Jianmei
Source	PMC
abstract	The flavonoid-rich extract from Paulownia fortunei flowers (EPF) has been reported to prevent obesity and other lipid metabolism disease. However, the mechanism of its protective effects is not yet clear. The objective of this study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of EPF in obese mice fed a high-fat diet (HFD). Male h ICR (Institute of Cancer Research) mice were fed a HFD containing or not containing the EPF (50 or 100 mg/kg) for eight weeks. EPF reduced body weight gain, lipid accumulation in livers and levels of lipid, glucose and insulin in plasma as well as reduced insulin resistance as compared with the HFD group. EPF significantly decreased serum aminotransferase activity of the HFD group. We observed that EPF administration significantly increased the level of AMP-activated kinase (AMPK) phosphorylation and prevented fat deposits in livers and HepG2 cells, but these effects were blocked by compound C (an AMPK inhibitor). The protective effects of EPF were probably associated with the decrease in HMGCR, SREBP-1c and FAS expressions and the increase in CPT1 and phosphor-IRS-1 expressions. Our results suggest that EPF might be a potential natural candidate for the treatment and/or prevention of overweight and hepatic and metabolic-related alterations induced by HFD.
has issue date	2017-08-30(xsd:dateTime)
bibo:doi	10.3390/nu9090959
bibo:pmid	28867797
has license	cc-by
sha1sum (hex)	ef35abb710975a602c24e4eff920d99c022e9132
schema:url	https://doi.org/10.3390/nu9090959
resource representing a document's title	Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway
has PubMed Central identifier	PMC5622719
has PubMed identifier	28867797
schema:publication	Nutrients
resource representing a document's body	covid:ef35abb710975a602c24e4eff920d99c022e9132#body_text
is schema:about of	named entity 'effects' named entity 'Cancer Research' named entity 'hypolipidemic' named entity 'effects' named entity 'compared' named entity 'inhibitor' named entity 'factors' named entity 'cells' named entity 'potential' named entity 'Obesity' named entity 'Insulin' covid:arg/ef35abb710975a602c24e4eff920d99c022e9132 named entity 'However' named entity 'effects' named entity 'activity' named entity 'SREBP-1c' named entity 'diet' named entity 'candidate' named entity 'plasma' named entity 'natural' named entity 'alterations' named entity 'Pathway' named entity 'Hepatic' named entity 'FAS' named entity 'HepG2' named entity 'phosphor' named entity 'insulin resistance' named entity 'hypoglycemic' named entity 'hepatic' named entity 'AMPK' named entity 'Flavonoid' named entity 'Mice' named entity 'Paulownia fortunei' named entity 'Insulin Resistance' named entity 'hyperlipidemia' named entity 'berberine' named entity 'insulin' named entity 'insulin resistance' named entity 'HPLC' named entity 'obesity' named entity 'ICR mice' named entity 'AMPK' named entity 'anthocyanins' named entity 'HMGCR' named entity 'glucose transport' named entity 'insulin-resistance' named entity 'lipid' named entity 'control group' named entity 'HepG2 cells' named entity 'food intake' named entity 'mice' named entity 'anti-obesity' named entity 'fatty acid synthesis' named entity 'therapeutic effects' named entity 'hyperinsulinemia' named entity 'hyperlipidemia' named entity 'methanol' named entity 'AMPK' named entity 'control group' named entity 'mice' named entity 'luteolin' named entity 'relative density' named entity 'SREBP-1c' named entity 'glucose uptake' named entity 'lipid metabolism disorder' named entity 'body weight' named entity 'lipid metabolism' named entity 'blood insulin' named entity 'lipid' named entity 'IRS-1' named entity 'IRS' named entity 'liver tissue' named entity 'gluconeogenesis' named entity 'control group' named entity 'Sephadex'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software