About: Anti-RNA virus activity of polyoxometalates

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-RNA virus activity of polyoxometalates
Creator	Mori, Shuichi Shigeta, Shiro Yamamoto, Naoki Yamamoto, Norio Yamase, Toshihiro
Source	Elsevier; Medline; PMC
abstract	The anti-RNA virus activity of polyoxometalates (POM) is reviewed, with a special emphasis on the anti-respiratory virus activities. There are many causative agents of acute viral respiratory infections; and it is rather difficult to identify the relevant agent in a given case by rapid clinical means. During acute progress of infection before the definitive diagnosis is obtained physicians need to prescribe certain broad spectrum anti-viral drugs. A titanium containing polyoxotungstate, PM-523 exhibited potent anti-influenza virus (FluV) A and anti-respiratory syncytial virus (RSV) activities in vitro. Therapeutic effect of FluV A infected mice with aerosol inhalation of PM-523 was proven. A vanadium substituted polyoxotungstate, PM-1001 has antiviral activity against FluV A, RSV, parainfluenza virus (PfluV) type 2, Dengue fiver virus, HIV-1 and SARS coronavirus in vitro. Thus, POMs have been proven to be broad spectrum and non-toxic anti-RNA virus agents in both in vitro and in vivo experiments and are promising candidates for first-line therapeutics in acute respiratory diseases.
has issue date	2006-05-24(xsd:dateTime)
bibo:doi	10.1016/j.biopha.2006.03.009
bibo:pmid	16737794
has license	no-cc
sha1sum (hex)	ef3a4d93100c30ecb223f9b5bfdb636c6430d01c
schema:url	https://doi.org/10.1016/j.biopha.2006.03.009
resource representing a document's title	Anti-RNA virus activity of polyoxometalates
has PubMed Central identifier	PMC7118841
has PubMed identifier	16737794
schema:publication	Biomed Pharmacother
resource representing a document's body	covid:ef3a4d93100c30ecb223f9b5bfdb636c6430d01c#body_text
is schema:about of	named entity 'definitive' named entity 'broad' named entity 'RSV' named entity 'inhalation' named entity 'AGENT' named entity 'CASE' named entity 'TO IDENTIFY' named entity 'IN VITRO' named entity 'DENGUE' named entity 'NEED' named entity 'CLINICAL' named entity 'SARS CORONAVIRUS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'VIRAL' named entity 'REVIEWED' named entity 'TOXIC' named entity 'RATHER' named entity 'DIFFICULT' named entity 'NON-' named entity 'LINE' named entity 'PARAINFLUENZA VIRUS' named entity 'RSV' named entity 'CAUSATIVE AGENTS' named entity 'POMS' named entity 'INHALATION' named entity 'THERAPEUTICS' named entity 'MICE' named entity 'ANTIVIRAL ACTIVITY' named entity 'EXPERIMENTS' named entity 'BROAD SPECTRUM' named entity 'RESPIRATORY INFECTIONS' named entity 'INFLUENZA VIRUS' named entity 'SPECIAL' named entity 'PHYSICIANS' named entity 'RNA VIRUS' named entity 'ACTIVITY' named entity 'HIV-1' named entity 'DEFINITIVE DIAGNOSIS' named entity 'AEROSOL' named entity 'GIVEN' named entity 'VANADIUM' named entity 'PROGRESS' named entity 'MEANS' named entity 'TITANIUM' named entity 'ACUTE' named entity 'ACTIVITY' named entity 'RNA VIRUS' named entity 'RAPID' named entity 'ANTIVIRAL DRUGS' named entity '523' named entity 'RESPIRATORY DISEASES' named entity 'INFECTION' named entity 'CERTAIN' named entity 'ACTIVITIES' named entity 'PROVEN' named entity 'INFECTED' named entity 'RESPIRATORY VIRUS' named entity 'RELEVANT' named entity 'CONTAINING' named entity 'OBTAINED' named entity 'THERAPEUTIC EFFECT' named entity 'FIVER' named entity 'IN VIVO' named entity 'VIRUS' named entity 'TYPE 2' named entity 'HAVE' covid:arg/ef3a4d93100c30ecb223f9b5bfdb636c6430d01c named entity 'activity' named entity 'spectrum' named entity 'virus' named entity 'acute' named entity 'There' named entity 'candidates' named entity 'virus' named entity 'virus' named entity 'antiviral drugs' named entity 'The'

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