About: Medicinal plants of the genus Betula—Traditional uses and a phytochemical

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About: Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review
Creator	Rastogi, Subha Kumar, Singh Madan, Mohan Pandey, Ajay Rawat,
topic	covid:efa1265bf6ce581da6c4e2ab9358df582a2cdb12#this
source	Elsevier; Medline; PMC
abstract	Abstract Ethnopharmacological relevance Trees and shrubs of the genus Betula (Betulaceae) inhabit various ecosystems in temperate and boreal climate zones of the northern hemisphere. The healing properties of Betula bark and bark extracts have been known for a long time in traditional medicine in different parts of the world. Several species of Betula have traditionally been used for the treatment of various inflammatory diseases including arthritis. The purpose of this review is to provide updated, comprehensive and categorized information on the botany, traditional uses, phytochemistry and pharmacological and toxicological research of Betula species in order to explore their therapeutic potential and evaluate future research opportunities. Materials and methods All the available information on various species belonging to the genus Betula was collected via electronic search (using Pubmed, SciFinder, Scirus, Google Scholar, JCCC@INSTIRC and Web of Science) and a library search for articles published in peer-reviewed journals. Results Although over a hundred Betula species are found distributed globally, about 7 different species of Betula have been documented for their traditional uses. Phytochemical research on Betula species has led to the isolation of triterpenoids, diarylheptanoids, phenylbutanoids, lignans, phenolics and flavonoids. Crude extracts, fractions and phytochemical constituents isolated from Betula showed a wide spectrum of in vitro and in vivo pharmacological activities like immunomodulatory, anti-inflammatory, antimicrobial, antiviral, antioxidant, antidiabetic, dermatological, gastroprotective and hepatoprotective. Antiarthritic and anticancer are the two major areas of research conducted on these species. The anti-carcinogenic effects of Betula bark, betulin as well as betulinic acid have been extensively studied. Conclusions Several species belonging to the genus Betula are widely used in traditional medicine. Betula platyphylla and Betula pendula have specifically been found to be potentially useful in the treatment of degenerative joint disease. There is convincing evidence in experimental animal models in support of their anti-carcinogenic effects. However, it would be worthwhile to investigate the biochemical and physiological mechanisms as well as detailed preclinical toxicity, bioavailability, pharmacokinetics and pharmacodynamics of the different biologically active extracts as well as molecules in sufficient detail. An integrated and holistic approach is required for tapping the full potentials of this important genus.
has issue date	2015-01-15(xsd:dateTime)
bibo:doi	10.1016/j.jep.2014.11.010
bibo:pmid	25449458
has license	els-covid
sha1sum (hex)	efa1265bf6ce581da6c4e2ab9358df582a2cdb12
schema:url	https://doi.org/10.1016/j.jep.2014.11.010
resource representing a document's title	Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review
has PubMed Central identifier	PMC7126499
has PubMed identifier	25449458
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:efa1265bf6ce581da6c4e2ab9358df582a2cdb12#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/efa1265bf6ce581da6c4e2ab9358df582a2cdb12
is schema:about of	named entity 'TRADITIONAL' named entity 'REVIEW' named entity 'PHARMACOLOGICAL' named entity 'GENUS' named entity 'PHYTOCHEMICAL' named entity 'MEDICINAL PLANTS' named entity 'BETULA' named entity 'USES' named entity 'Medicinal plants' named entity 'genus' named entity 'Betula' named entity 'parainfluenza virus' named entity 'dendritic cell' named entity 'wheat' named entity 'Bhuj' named entity 'Betula pendula' named entity 'Greenland' named entity 'gout' named entity 'leukemia' named entity 'sap' named entity 'antigen' named entity 'rheumatism' named entity 'stamens' named entity 'butylated hydroxyanisole' named entity 'corneal inflammation' named entity 'Betula ermanii' named entity 'Pseudomonas aeruginosa' named entity 'mast cells' named entity 'Betula pendula' named entity 'keratinocytes' named entity 'methyl gallate' named entity 'Actinic keratoses' named entity 'Betula species' named entity 'amide' named entity 'Apoptosis' named entity 'Fig' named entity 'mast cells' named entity 'gene sequences' named entity 'Antidiabetic' named entity 'free radical' named entity 'HSV-1' named entity 'birch bark' named entity 'citric acid' named entity 'hydrophilic' named entity 'Betula platyphylla' named entity 'IL-12p70' named entity 'amino acid' named entity 'Google Scholar' named entity 'sepals' named entity 'rheumatism' named entity 'membrane stabilization' named entity 'ethanol' named entity 'autumn color' named entity 'heptene' named entity 'antiinflammatory' named entity 'actinic keratoses' named entity 'VSV' named entity 'Betula ermanii' named entity 'raw material' named entity 'cytokine' named entity 'birch bark' named entity 'rheumatoid arthritis' named entity 'COX-2' named entity 'Fig' named entity 'volatile oil' named entity 'IL-1β' named entity 'metal-chelating' named entity 'bone marrow' named entity 'quercetin' named entity 'lymph node' named entity 'fibroblast' named entity 'Betula pendula' named entity 'squamous cell carcinoma' named entity 'antiinflammatory' named entity 'Lupeol'

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