About: Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)

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About: Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)
Creator	Bailey, Michael Beasley, Richard Young, Paul Bellomo, Rinaldo Deane, Adam Eastwood, Glenn Finfer, Simon Freebairn, Ross King, Victoria Linke, Natalie Litton, Edward Mackle, Diane Mcarthur, Colin Mcguinness, Shay Panwar, Rakshit
Source	PMC
abstract	PURPOSE: Sepsis is a common reason for intensive care unit (ICU) admission and mortality in ICU patients. Despite increasing interest in treatment strategies limiting oxygen exposure in ICU patients, no trials have compared conservative vs. usual oxygen in patients with sepsis. METHODS: We undertook a post hoc analysis of the 251 patients with sepsis enrolled in a trial that compared conservative oxygen therapy with usual oxygen therapy in 1000 mechanically ventilated ICU patients. The primary end point for the current analysis was 90-day mortality. Key secondary outcomes were cause-specific mortality, ICU and hospital length of stay, ventilator-free days, vasopressor-free days, and the proportion of patients receiving renal replacement therapy in the ICU. RESULTS: Patients with sepsis allocated to conservative oxygen therapy spent less time in the ICU with an SpO(2) ≥ 97% (23.5 h [interquartile range (IQR) 8–70] vs. 47 h [IQR 11–93], absolute difference, 23 h; 95% CI 8–38), and more time receiving an FiO(2) of 0.21 than patients allocated to usual oxygen therapy (20.5 h [IQR 1–79] vs. 0 h [IQR 0–10], absolute difference, 20 h; 95% CI 14–26). At 90-days, 47 of 130 patients (36.2%) assigned to conservative oxygen and 35 of 120 patients (29.2%) assigned to usual oxygen had died (absolute difference, 7 percentage points; 95% CI − 4.6 to 18.6% points; P = 0.24; interaction P = 0.35 for sepsis vs. non-sepsis). There were no statistically significant differences between groups for secondary outcomes but point estimates of treatment effects consistently favored usual oxygen therapy. CONCLUSIONS: Point estimates for the treatment effect of conservative oxygen therapy on 90-day mortality raise the possibility of clinically important harm with this intervention in patients with sepsis; however, our post hoc analysis was not powered to detect the effects suggested and our data do not exclude clinically important benefit or harm from conservative oxygen therapy in this patient group. CLINICAL TRIALS REGISTRY: ICU-ROX Australian and New Zealand Clinical Trials Registry number ACTRN12615000957594. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-019-05857-x) contains supplementary material, which is available to authorized users.
has issue date	2019-11-20(xsd:dateTime)
bibo:doi	10.1007/s00134-019-05857-x
bibo:pmid	31748836
has license	no-cc
sha1sum (hex)	efa683dbf25a9a97d68621e75798c7941a71b2b5
schema:url	https://doi.org/10.1007/s00134-019-05857-x
resource representing a document's title	Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)
has PubMed Central identifier	PMC7223684
has PubMed identifier	31748836
schema:publication	Intensive Care Med
resource representing a document's body	covid:efa683dbf25a9a97d68621e75798c7941a71b2b5#body_text
is schema:about of	named entity 'patients' named entity 'intensive care unit (ICU)' named entity 'post hoc' named entity 'data' named entity 'STRATEGIES' named entity 'ADMISSION' named entity 'Purpose' named entity 'patients' named entity 'Sepsis' named entity 'mechanically ventilated' named entity 'Intensive Care Society' named entity 'organ dysfunction' named entity 'infection' named entity 'post hoc analysis' named entity 'ICU' named entity 'statistician' named entity 'sepsis' named entity 'non-significant' named entity 'random variable' named entity 'treatment groups' named entity 'oxygen' named entity 'New Zealand' named entity 'end point' named entity 'Fisher's exact test' named entity 'oxygen therapy' named entity 'dichotomous' named entity 'ICU' named entity 'oxygen' named entity 'sepsis' named entity '0.21' named entity 'RCT' named entity 'treatment group' named entity 'oxygen therapy' named entity 'RCT' named entity 'treatment groups' named entity 'treatment group' named entity 'post hoc analysis' named entity 'oxygen' named entity 'mortality rates' named entity 'sepsis' named entity 'oxygen' named entity 'oxygen therapy' named entity 'post hoc' named entity 'simplex algorithm' named entity 'oxygen delivery' named entity 'sepsis' named entity 'sepsis' named entity 'confidence intervals' named entity 'intensive care unit' named entity 'absolute difference' named entity 'ICU' named entity 'oxygen' named entity 'oxygen' named entity 'infection' named entity 'oxygen tension' named entity 'infection' named entity 'Australia' named entity 'Plus-minus' named entity 'saline' named entity 'post hoc' named entity 'oxygen' named entity 'sepsis' named entity 'New Zealand' named entity 'oxygen therapy' named entity 'subcode' named entity 'oxygen' named entity 'sepsis'

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