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About:
The Relationship of Rhinovirus-Associated Asthma Hospitalizations with Inhaled Corticosteroids and Smoking
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schema:ScholarlyArticle
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
The Relationship of Rhinovirus-Associated Asthma Hospitalizations with Inhaled Corticosteroids and Smoking
Creator
Gebretsadik, Tebeb
Griffin, Marie
Busse, William
Hartert, Tina
Minton, Patricia
Stokes Peebles, R
Vrtis, Rose
Hamilton, Robert
Higgins, Stanley
Shintani, Ayumi
Venarske, Daniel
Weisshaar, Elizabeth
Source
Medline; PMC
abstract
BackgroundAlthough rhinovirus (RV) respiratory infections trigger asthma exacerbations, the etiologic association between this virus and severe exacerbations, as well as the clinical characteristics of adults at risk for RV-associated asthma that necessitates hospitalization, have not been established MethodsDuring 1999–2003, we conducted a cohort study of 101 adults prospectively enrolled at hospital admission for an asthma exacerbation. Patient characteristics and frequencies of RV in nasal specimens were analyzed, by reverse-transcription polymerase chain reaction (RT-PCR), at asthma-related hospital admission and at a 3-month convalescent follow-up visit ResultsRV was detected by RT-PCR in 21% of hospitalized patients over a 4-year period and in 1.3% of patients who returned for a 3-month follow-up visit. RV detection was strongly associated with hospitalization for asthma (adjusted odds ratio [OR], 15.1 [95% confidence interval {CI}, 1.88–121.4]). After adjustment for baseline asthma severity, RV-positive patients were more likely than RV-negative patients to be current smokers and nonusers of inhaled corticosteroids (ICSs) (adjusted OR, 11.18 [95% CI, 2.37–52.81]; P=.002) ConclusionsRV respiratory infection is an etiologic agent in severe asthma exacerbations necessitating hospitalization in adults. Compared with hospitalized patients with asthma who were RV negative, RV-positive patients were significantly more likely to be smokers and nonusers of ICSs
has issue date
2006-06-01
(
xsd:dateTime
)
bibo:doi
10.1086/503809
bibo:pmid
16652282
has license
no-cc
sha1sum (hex)
efc50ae4c08699212311dc5f0f5cd335b88f1415
schema:url
https://doi.org/10.1086/503809
resource representing a document's title
The Relationship of Rhinovirus-Associated Asthma Hospitalizations with Inhaled Corticosteroids and Smoking
has PubMed Central identifier
PMC7109695
has PubMed identifier
16652282
schema:publication
J Infect Dis
resource representing a document's body
covid:efc50ae4c08699212311dc5f0f5cd335b88f1415#body_text
is
schema:about
of
named entity 'ASTHMA EXACERBATIONS'
named entity 'RHINOVIRUS'
named entity 'ASSOCIATION'
named entity 'ASSOCIATED'
named entity 'ASSOCIATED'
named entity 'INHALED'
named entity 'SMOKING'
named entity 'HOSPITALIZATIONS'
named entity 'ASTHMA'
named entity 'ESTABLISHED'
named entity 'HAVE'
named entity 'ADULTS'
named entity 'SEVERE'
named entity 'RESPIRATORY INFECTIONS'
named entity 'TRIGGER ASTHMA'
named entity 'RHINOVIRUS'
named entity 'ASTHMA'
named entity 'CLINICAL CHARACTERISTICS'
named entity 'AT RISK'
named entity 'HOSPITALIZATION'
named entity 'CORTICOSTEROIDS'
named entity 'RELATIONSHIP'
named entity 'VIRUS'
covid:arg/efc50ae4c08699212311dc5f0f5cd335b88f1415
named entity 'trigger'
named entity 'hospitalization'
named entity 'adults'
named entity 'severe'
named entity 'asthma'
named entity 'virus'
named entity 'respiratory infections'
named entity 'epithelium'
named entity 'viral culture'
named entity 'community-acquired pneumonia'
named entity 'viruses'
named entity 'antivirals'
named entity 'risk factors'
named entity 'asthma'
named entity 'generalized estimating equation'
named entity 'intensive care unit'
named entity 'asthma exacerbations'
named entity 'infection'
named entity 'infection'
named entity '95% CI'
named entity 'agonist'
named entity 'acute asthma'
named entity 'follow-up'
named entity 'PCR'
named entity 'sucrose'
named entity 'statistically significant'
named entity 'serially diluted'
named entity 'wheezing'
named entity 'asthma exacerbations'
named entity 'smoke tobacco'
named entity 'PCR'
named entity 'infection'
named entity 'respiratory distress'
named entity 'tobacco smoke'
named entity 'infection'
named entity 'Second-hand smoke'
named entity 'epithelium'
named entity 'infection'
named entity 'RT-PCR'
named entity 'PCR'
named entity 'risk factor'
named entity 'Promega'
named entity 'ng/mL'
named entity 'asthma'
named entity '21%'
named entity 'ng/mL'
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