About: Class I HLA allele restricted antigenic coverage for Spike and N proteins is associated with divergent outcomes for COVID-19

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About: Class I HLA allele restricted antigenic coverage for Spike and N proteins is associated with divergent outcomes for COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Class I HLA allele restricted antigenic coverage for Spike and N proteins is associated with divergent outcomes for COVID-19
Creator	Antônio, Marco Boroni, Mariana Bonamino, Martín Bonomo, Fioravanti, Gustavo Galvani1, Rômulo Pretti, M
Source	MedRxiv
abstract	The world is dealing with the worst pandemics ever. SARS-CoV-2 is the etiological agent of COVID-19 that has already spread to more than 200 countries. However, infectivity, severity and mortality rates do not affect all countries equally. Here we investigate the landscape of potential HLA-I A and B restricted SARS-CoV-2-derived antigens and how different populations in the world are predicted to respond to those peptides considering their HLA-I distribution frequencies. Clustering of HLA-A and HLA-B allele frequencies partially separates most countries with the lowest number of deaths per million inhabitants from the other countries. We further correlated the patterns of in silico predicted strong binder peptides and epidemiological data. The number of deaths per million inhabitants inversely correlated with the antigen coverage of peptides derived from viral protein S, while a direct correlation was observed for those derived from viral protein N, highlighting a potential risk group carrying HLAs associated with the latter. In addition, we identified 7 potential antigens bearing at least one amino acid of the small insertion that differentiates SARS-CoV-2 from previous coronavirus strains. We believe these data can contribute to the search for peptides with the potential to be used in vaccine strategies.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.03.20121301
has license	medrxiv
sha1sum (hex)	efe2cd737e873a8dd47179cdbe7ba1abdccee7a4
schema:url	https://doi.org/10.1101/2020.06.03.20121301
resource representing a document's title	Class I HLA allele restricted antigenic coverage for Spike and N proteins is associated with divergent outcomes for COVID-19
resource representing a document's body	covid:efe2cd737e873a8dd47179cdbe7ba1abdccee7a4#body_text
is schema:about of	named entity 'affect' named entity 'pandemics' named entity 'PANDEMICS' named entity 'INFECTIVITY' named entity 'COVID-19' named entity 'AFFECT' named entity 'HERE' named entity 'HOW' named entity 'SARS-COV-2' named entity 'CONSIDERING' named entity 'mortality rates' named entity 'HLA' named entity 'COVID-19' named entity 'infectivity' named entity 'COVID-19' named entity 'populations' named entity 'HLA' named entity 'significant difference' named entity 'SARS-CoV-2' named entity 'alleles' named entity 'ACE2' named entity 'HLA' named entity 'peptides' named entity 'immunogenicity' named entity 'CD8' named entity 'present antigens' named entity 'alleles' named entity 'mortality rates' named entity 'COVID' named entity 'Peptides' named entity 'allelic' named entity 'GRE' named entity 'alveolar epithelial cells' named entity 'SARS' named entity 'medRxiv' named entity 'genotypic frequencies' named entity 'peptides' named entity 'SGP' named entity 'receptor binding' named entity 'human body' named entity 'COVID-19' named entity 'viral protein' named entity 'epidemiological' named entity 'peptides' named entity 'CC-BY-NC-ND 4.0' named entity 'HLA-B' named entity 'vaccination' named entity 'Nucleocapsid' named entity 'peptides' named entity 'vaccine' named entity 'pandemics' named entity 'Antigen' named entity 'HLA' named entity 'immunogenic' named entity 'alleles' named entity 'ligand' named entity 'etiological agent' named entity 'SARS-CoV-2' named entity 'confidence interval' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'HLA' named entity 'peptide' named entity 'peer review' named entity 'peptides' named entity 'peptides' named entity 'SARS-CoV-2' named entity 'Nucleocapsid' named entity 'lymphocytes' named entity 'HLA' named entity 'inflammatory response' named entity 'peptides' named entity 'peptides' named entity 'SARS' named entity 'peptides' named entity 'cytokine' named entity 'HLA-A' named entity 'correlation' named entity 'SARS-CoV-2' named entity 'infection'

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