About: A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study

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About: A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study
Creator	Piastra, Marco De Silvestri, Annalisa Amigoni, Angela Conti, Giorgio D'amato 11, Luigia Gitto, Eloisa Mondardini, Maria Montani, Cinzia Pizzi, Simone Rossetti, Emanuele Santuz, Pierantonio Savron, Fabio Tinelli, Carmine Wolfler, Andrea
Source	PMC
abstract	BACKGROUND: Pediatric ARDS still represents a difficult challenge in Pediatric Intensive Care Units (PICU). Among different treatments proposed, exogenous surfactant showed conflicting results. Aim of this multicenter retrospective observational study was to evaluate whether poractant alfa use in pediatric ARDS might improve gas exchange in children less than 2 years old, according to a shared protocol. METHODS: The study was carried out in fourteen Italian PICUs after dissemination of a standardized protocol for surfactant administration within the Italian PICU network. The protocol provides the administration of surfactant (50 mg/kg) divided in two doses: the first dose is used as a bronchoalveolar lavage while the second as supplementation. Blood gas exchange variations before and after surfactant use were recorded. RESULTS: Sixty-nine children, age 0–24 months, affected by Acute Respiratory Distress Syndrome treated with exogenous porcine surfactant were enrolled. Data collection consisted of patient demographics, respiratory variables and arterial blood gas analysis. The most frequent reasons for PICU admission were acute respiratory failure, mainly bronchiolitis and pneumonia, and septic shock. Fifty-four children (78.3%) had severe ARDS (define by oxygen arterial pressure and inspired oxygen fraction ratio (P/F) < 100), 15 (21.7%) had moderate ARDS (100 < P/F < 200). PO(2), P/F, Oxygenation Index (OI) and pH showed a significant improvement after surfactant use with respect to baseline (p < 0.001 at each included time-point for each parameter). No significant difference in blood gas variations were observed among four different subgroups of diseases (bronchiolitis, pneumonia, septic shock and others). Overall, 11 children died (15.9%) and among these, 10 (90.9%) had complex chronic conditions. Two children (18.2%) died while being treated with Extracorporeal Membrane Oxygenation (ECMO). Mortality for severe pARDS was 20.4%. CONCLUSION: The use of porcine Surfactant improves oxygenation, P/F ratio, OI and pH in a population of children with moderate or severe pARDS caused by multiple diseases. A shared protocol seems to be a good option to obtain the same criteria of enrollment among different PICUs and define a unique way of use and administration of the drug for future studies.
has issue date	2019-06-18(xsd:dateTime)
bibo:doi	10.1186/s12887-019-1579-3
bibo:pmid	31215483
has license	cc-by
sha1sum (hex)	efe9c08c881908c9a617c23c8b0ae9e8c7307dbd
schema:url	https://doi.org/10.1186/s12887-019-1579-3
resource representing a document's title	A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study
has PubMed Central identifier	PMC6580470
has PubMed identifier	31215483
schema:publication	BMC Pediatr
resource representing a document's body	covid:efe9c08c881908c9a617c23c8b0ae9e8c7307dbd#body_text
is schema:about of	named entity 'ARDS' named entity 'respect' named entity 'blood gas' named entity 'Blood gas' named entity 'variations' named entity 'drug' named entity 'porcine' named entity 'acute respiratory distress syndrome' named entity 'CONFLICTING' named entity 'BRONCHIOLITIS' named entity 'PARDS' named entity 'COMPLEX' named entity 'SECOND' named entity 'OXYGENATION' named entity 'BLOOD GAS' named entity 'PORACTANT ALFA' named entity 'ADMINISTRATION' named entity 'MORTALITY' named entity 'SIXTY-NINE' named entity 'REASONS' named entity 'VARIATIONS' named entity 'SEVERE' named entity '28P' named entity 'BACKGROUND' named entity 'EXTRACORPOREAL MEMBRANE OXYGENATION' named entity 'SIGNIFICANT' named entity 'FOURTEEN' named entity 'DOSES' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'DIED' named entity 'FIFTY' named entity 'acute respiratory failure' named entity 'variables' named entity 'pediatric' named entity 'surfactant' named entity 'arterial blood gas' named entity 'children' named entity 'protocol' named entity 'define' named entity 'oxygen' named entity 'ratio' named entity 'evaluate' named entity 'ARDS' named entity 'Pediatric' named entity 'Pediatric' named entity 'surfactant' named entity 'PICU' named entity 'surfactant' named entity 'PICU' named entity 'PICU' named entity 'pediatric' named entity 'Intensive Care Units' named entity 'chronic conditions' named entity 'oxygen' named entity 'pediatric acute respiratory distress syndrome' named entity 'admission' named entity 'bronchiolitis' named entity 'arterial blood gas' named entity 'ventilatory support' named entity 'severe respiratory failure' named entity 'chronic condition' named entity 'nutrition' named entity 'respiratory failure' named entity 'Berlin' named entity 'demographic characteristics' named entity 'Odds Ratio' named entity 'STATA' named entity 'gas exchange'

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